ID A0A1H9W0L4_9ACTN Unreviewed; 551 AA.
AC A0A1H9W0L4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN04487983_103946 {ECO:0000313|EMBL:SES27344.1};
OS Streptomyces sp. yr375.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1761906 {ECO:0000313|EMBL:SES27344.1, ECO:0000313|Proteomes:UP000198568};
RN [1] {ECO:0000313|EMBL:SES27344.1, ECO:0000313|Proteomes:UP000198568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YR375 {ECO:0000313|EMBL:SES27344.1,
RC ECO:0000313|Proteomes:UP000198568};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; FOFF01000039; SES27344.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9W0L4; -.
DR STRING; 1761906.SAMN04487983_103946; -.
DR Proteomes; UP000198568; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SES27344.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000198568};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 310..519
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT REGION 146..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..230
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..534
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 551 AA; 58219 MW; 799109D63E0370C5 CRC64;
MSGDGRPGRL KVYLGAAPGV GKTYRMLDEA RRRAARGADV VVGFAECHGR PRTEAMLDGL
EVVPRARCVH RGGECEEMDL AAVLARRPQV AVVDEFAHRN VPGDGRNAMR RQDIEAETMS
SLARSIVRGD ATIPALLERT RETFGMNSAE LVTEPPDAES LDPEPLDRSP LDAESSDAEP
LAPSLLDAES SDAEPLASSP LDAEPPDPEP LDRPPLNAEP PAPEPPDAEP PDAEGVTAVT
PVTAVTVVPA GPGAYLLLRG RSLSGSERRV LAAFAAHVGA AVERARLAEA VAEVEPVKAA
DRMRTALLRA VGHDLRTPLA AGWAAVTSLR SRDVEFTPED RDELLATADE SMAKLSRLVE
NLLDLSRLEA GVLPLNLRAT TLEEVLPTAL ADVPVAEARD VERIPAVLAD PPLLERVVAN
LVGNAARHTP PGQQVLVTAS ALAGRVELRV VDRGPGLPAD GRERLFEPFQ RLGDTNNTTG
LGLGLALARG LTEAMNGTLT PEDTPGGGLT MVVSLPCAQQ DEERRTDPDG RDAGRSEAGS
PPFDEALATG L
//
