ID   A0A1H9W3E2_9PSEU        Unreviewed;       590 AA.
AC   A0A1H9W3E2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=Ribonucleoside-diphosphate reductase class II {ECO:0000313|EMBL:SES28470.1};
GN   ORFNames=SAMN05216188_13054 {ECO:0000313|EMBL:SES28470.1};
OS   Lentzea xinjiangensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Lentzea.
OX   NCBI_TaxID=402600 {ECO:0000313|EMBL:SES28470.1, ECO:0000313|Proteomes:UP000199352};
RN   [1] {ECO:0000313|Proteomes:UP000199352}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.3525 {ECO:0000313|Proteomes:UP000199352};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
CC         Evidence={ECO:0000256|ARBA:ARBA00001922};
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DR   EMBL; FOFR01000030; SES28470.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H9W3E2; -.
DR   STRING; 402600.SAMN05216188_13054; -.
DR   OrthoDB; 9762933at2; -.
DR   Proteomes; UP000199352; Unassembled WGS sequence.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.70.20; -; 1.
DR   InterPro; IPR000788; RNR_lg_C.
DR   PANTHER; PTHR43371:SF1; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE; 1.
DR   PANTHER; PTHR43371; VITAMIN B12-DEPENDENT RIBONUCLEOTIDE REDUCTASE; 1.
DR   Pfam; PF02867; Ribonuc_red_lgC; 1.
DR   PRINTS; PR01183; RIBORDTASEM1.
DR   SUPFAM; SSF51998; PFL-like glycyl radical enzymes; 1.
PE   4: Predicted;
KW   Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW   Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW   DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          199..546
FT                   /note="Ribonucleotide reductase large subunit C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02867"
SQ   SEQUENCE   590 AA;  61466 MW;  079FD9879DDBA16B CRC64;
     MYRSTFPTTP HREAYLRTGR IISGGETVQD MVTRIVTALE LADARFDPAG AEAFGERLGW
     AMDTERIVFS PSIMTNAGRS ADRPPAACTV DLRGDLAEVK TIVDGYHQAG MGTGFLLDGL
     DDPVGVLRYL NDIAVASANC GDGLVGNMAI LSLDHPRAED FIGCKIGADA RGEAWKFTIA
     LQVTDAQMRA ALSAPGRERQ LLIAAAEAAH ACADPGLLFA DRLGDGNPTP RDGAYVRTAP
     CAEVGLVAGE TCQFGYLNLG RFHTGGGTIP VDLDALADTT RTLVRALDDA IAASLQRYPN
     PLSAQVMGVN RKIGVGVCGL ADLLLAAGLP YDSAEARRLT QEVLALVNYT SKLASAELAR
     DRGACPAVGG GRSRYAQPAF LRRFAELGTT TVTRGDWNAL AARIAQTGLL RNSCTVAVPP
     TGRSAPVVGA STGIEPLVRL SGDQPGHRRA AVVAALQHAG RTDVLGFVDT CGRLPADPTL
     PERLRVLLAT ATQISPAGHL AMAAAVQACV DEPVSATVPL PGTARAIDVY DIFATAFELG
     CKGITVSRPA THSPYNTSVV SVASGAHAAM PAVLRPLPSA CPLPPAASPN
//