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Database: UniProt
Entry: A0A1H9WC99_9PSEU
LinkDB: A0A1H9WC99_9PSEU
Original site: A0A1H9WC99_9PSEU 
ID   A0A1H9WC99_9PSEU        Unreviewed;       701 AA.
AC   A0A1H9WC99;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   08-MAY-2019, entry version 9.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SES31093.1};
GN   ORFNames=SAMN04487818_11026 {ECO:0000313|EMBL:SES31093.1};
OS   Actinokineospora terrae.
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Actinokineospora.
OX   NCBI_TaxID=155974 {ECO:0000313|EMBL:SES31093.1, ECO:0000313|Proteomes:UP000199051};
RN   [1] {ECO:0000313|EMBL:SES31093.1, ECO:0000313|Proteomes:UP000199051}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44260 {ECO:0000313|EMBL:SES31093.1,
RC   ECO:0000313|Proteomes:UP000199051};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
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DR   EMBL; FOGI01000010; SES31093.1; -; Genomic_DNA.
DR   BioCyc; GCF_900111175:BMY07_RS22935-MONOMER; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000199051; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000199051};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199051}.
FT   DOMAIN      332    511       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      515    596       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   701 AA;  74211 MW;  6AA0B8DB5D374079 CRC64;
     MLTHEQAAKA FPDEVVTKAV TRLVRVAGLA KPVALITIDN GHDHTRPSTF GPQSLVSLNA
     AFDAAVAAQP SAIAVTGKPF IFAVGADLSG VEQVADRSSA VDIAQTGHDV FRRFTESPVP
     TFAFVNGAVL GGGLELALSC HYRTLSDNTA AIALPEVFLG LFPGWGGTQL LPNLIGPDAA
     VTVIFENALS QNRMLKPAQA AELGITDVLL GSADFIERSL AWASDVVNGV VSVPRKEIDR
     GAGWNTAVER AKGIVHGRTK GASPGALKAL ELLELARAND LDAGYAAETE ALADVLMTDP
     LRAGLYSFTL VQKRAKRPAG APDKSLARPV TKVGVVGAGL MASQMALLFV RQLKVPVVLT
     DIDQARVDKG VAYVHDEIDK LGARGRLSPD GVNRLTALVS GSLDKAAFAD ADFVIEAVFE
     ELGVKQKVFA EVEAHVSAEC VLATNTSSLS ITEMAAGLAH PERVVGFHFF NPVAVMPLLE
     VVRAERTDDA TLATAFAVGK ALRKSSVLVK DAPAFVVNRL LTRFMGEVVR AIDEGTPFEV
     ADRATEPLGL PMSPLVLLQL VGAPVALHVA ETMHRAYPDR FGVSENMRRF VAAGKNAVWT
     WDSAGNQSVD PEVAALWQFG PNPLTAQEVL DRVLDAMAEE IRIMLDEGVV AEAQDIDLCL
     LLGAGWPFWL GGVTPYLDRA GVSERVHGKP FLAPGVASVP A
//
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