ID   A0A1H9WE97_9MICO        Unreviewed;       579 AA.
AC   A0A1H9WE97;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN   ORFNames=SAMN05216199_2846 {ECO:0000313|EMBL:SES32240.1};
OS   Pedococcus cremeus.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC   Pedococcus.
OX   NCBI_TaxID=587636 {ECO:0000313|EMBL:SES32240.1, ECO:0000313|Proteomes:UP000199019};
RN   [1] {ECO:0000313|Proteomes:UP000199019}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.6963 {ECO:0000313|Proteomes:UP000199019};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC       D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU365092};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU365092}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the lactate permease family.
CC       {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
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DR   EMBL; FOHB01000005; SES32240.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H9WE97; -.
DR   STRING; 587636.SAMN05216199_2846; -.
DR   OrthoDB; 9761056at2; -.
DR   Proteomes; UP000199019; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR003804; Lactate_perm.
DR   InterPro; IPR001763; Rhodanese-like_dom.
DR   PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR   PANTHER; PTHR30003:SF2; L-LACTATE PERMEASE; 1.
DR   Pfam; PF02652; Lactate_perm; 2.
DR   PROSITE; PS50206; RHODANESE_3; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU365092};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199019};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365092};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365092};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM        23..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        120..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        196..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        255..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        340..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        393..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        527..546
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        552..577
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   DOMAIN          194..236
FT                   /note="Rhodanese"
FT                   /evidence="ECO:0000259|PROSITE:PS50206"
FT   REGION          304..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   579 AA;  59236 MW;  BA246B73D27386B1 CRC64;
     MPLPSLTLGQ QAQTALTAVP LPTWLLAVSP VVLLLALVLW GRFSTIVNAL TTVAYSVVVA
     VVAFGAGPLT VAVGLGKGAW VGVWILYVIW PALLMHHLAS HVGMTALGRA LSTLLPRRTE
     NVLLLAWVLP SFIQGVSGFG TPIAVAAPLL VALGVSTTRA VALPLIGYHW AVGFGSMGSS
     FYMGALTAHL DTAERAGYAA AAAVVLGINC VVSGVLVALM DGGWGGLRQG WRMLLTAGPV
     MALVQAGAAR LEPGIGALCA GASGIAVVLV LRVLTRRGER PSELGTAEPV GVAAGHATAY
     RSRLEPDLPR AHGSEPRGSA TGPDDGESAE RTRERARAAA VPYALLGVIA LAVFLPPALR
     AWAKGHLLLG PAFPQTTTSH GTVNDAVDLY NPIALVGHPG TFLLLACLGS VLVWRRIGVW
     GRGAWGPVWR GALRQAWKSS PSVVLLASVA GVLVDSGMVR TVAQGAAVAT GHAYPAIAPL
     VGALGSFITG STTSSNALFS SLQADVAHLV GDRPADLLAG QLAGGNIGNS LAPVVILLGL
     SAVGAARRTG EVLRLTLLPA AVLLLSAVTA TWVLVALHR
//