ID A0A1H9XDA9_9ACTN Unreviewed; 799 AA.
AC A0A1H9XDA9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Zn-dependent metalloprotease {ECO:0000313|EMBL:SES43643.1};
GN ORFNames=SAMN04487983_105426 {ECO:0000313|EMBL:SES43643.1};
OS Streptomyces sp. yr375.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1761906 {ECO:0000313|EMBL:SES43643.1, ECO:0000313|Proteomes:UP000198568};
RN [1] {ECO:0000313|EMBL:SES43643.1, ECO:0000313|Proteomes:UP000198568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YR375 {ECO:0000313|EMBL:SES43643.1,
RC ECO:0000313|Proteomes:UP000198568};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M4 family.
CC {ECO:0000256|ARBA:ARBA00009388}.
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DR EMBL; FOFF01000054; SES43643.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9XDA9; -.
DR STRING; 1761906.SAMN04487983_105426; -.
DR OrthoDB; 291295at2; -.
DR Proteomes; UP000198568; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09597; M4_TLP; 1.
DR Gene3D; 3.10.170.10; -; 1.
DR Gene3D; 3.10.450.40; -; 1.
DR Gene3D; 3.10.450.490; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR011096; FTP_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR023612; Peptidase_M4.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR InterPro; IPR001570; Peptidase_M4_C_domain.
DR InterPro; IPR013856; Peptidase_M4_domain.
DR PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR Pfam; PF07504; FTP; 1.
DR Pfam; PF05345; He_PIG; 1.
DR Pfam; PF01447; Peptidase_M4; 1.
DR Pfam; PF02868; Peptidase_M4_C; 1.
DR PRINTS; PR00730; THERMOLYSIN.
DR SUPFAM; SSF49313; Cadherin-like; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000313|EMBL:SES43643.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:SES43643.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198568};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..799
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011560077"
FT DOMAIN 82..118
FT /note="FTP"
FT /evidence="ECO:0000259|Pfam:PF07504"
FT DOMAIN 225..372
FT /note="Peptidase M4"
FT /evidence="ECO:0000259|Pfam:PF01447"
FT DOMAIN 375..549
FT /note="Peptidase M4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02868"
FT ACT_SITE 365
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
FT ACT_SITE 452
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
SQ SEQUENCE 799 AA; 81633 MW; 689BACDF8D87E824 CRC64;
MRPNPRKRTT VGAALLSSAA LLALGVQTVP ATALPAAPHP GPLRTGSLPA DLTPAQRTTL
IKSAEARTTQ TADTLGLGAQ EKLVVKDVVK DNDGTVHTRY ERTYAGLPVL GGDLVVHTPP
ASVAAGTVST TFNNNRRTVS VRSTTATYSK TAAESKALTA AKALDAKDPA AQSARKVIWA
GEGTPKLAWE TVVSGLQDDG TPSKLHVITD AATGAKLSQY EGVETGTGNT QYSGTVSLST
TLSGSTYQLY DTTRGGHKTY SLNNATSGTG TLMTDSDDVW GTGAGSNTQT AGADAAYGAQ
ETWDFYKNTF GRSGIKNDGV AAYSRVHYSS AYVNAFWDDD CFCMTYGDGS GSTHALTSLD
VAGHEMSHGV TSNTAGLDYT GESGGLNEAT SDIFGTGVEF YANNSSDVGD YLIGEKIDIN
GDGTPLRYMD EPDKDGGSAD SWYSGVGNLD VHYSSGPANH MFYLLSEGSG SKTINGVTYN
SPTSDGVAVA GIGRAAALQI WYKALTTYMT SSTNYAGART AALSAAAALY GSSSAQYAGV
GNAFAGINVG SHITVPSTGV TVTNPGSQTA TVGTAVSLQL SASSTNSGTL TYAASGLPTG
LSISSTGLIS GTPTTAGTYS TTVTVTDSTG ATGTAAFTWT VGSTGGGSCT VTQLLGNNGF
ESGNTTWTAS SGVITNSSSQ AARTGSYKAW LDGYGSTHTD TLSQSVTIPS GCTNTTFTFY
LHVDTAETST STQYDKLTVT AGSTTLATYS NLNAASGYVQ KSLSLGSYAG STVALKFSGV
EDSSLQTSFV IDDTAVTTG
//