ID A0A1H9XN41_9PSEU Unreviewed; 1154 AA.
AC A0A1H9XN41;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DNA gyrase subunit A {ECO:0000256|ARBA:ARBA00026190};
GN ORFNames=SAMN04487818_11791 {ECO:0000313|EMBL:SES47511.1};
OS Actinokineospora terrae.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinokineospora.
OX NCBI_TaxID=155974 {ECO:0000313|EMBL:SES47511.1, ECO:0000313|Proteomes:UP000199051};
RN [1] {ECO:0000313|EMBL:SES47511.1, ECO:0000313|Proteomes:UP000199051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44260 {ECO:0000313|EMBL:SES47511.1,
RC ECO:0000313|Proteomes:UP000199051};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR EMBL; FOGI01000017; SES47511.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9XN41; -.
DR STRING; 155974.SAMN04487818_11791; -.
DR Proteomes; UP000199051; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00081; Hint; 1.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 1.
DR Gene3D; 3.10.28.10; Homing endonucleases; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 2.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR003586; Hint_dom_C.
DR InterPro; IPR003587; Hint_dom_N.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR030934; Intein_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR NCBIfam; TIGR01443; intein_Cterm; 1.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF00521; DNA_topoisoIV; 2.
DR SMART; SM00305; HintC; 1.
DR SMART; SM00306; HintN; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR SUPFAM; SSF55608; Homing endonucleases; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 2.
DR PROSITE; PS50818; INTEIN_C_TER; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000199051};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 392..415
FT /note="Intein C-terminal splicing"
FT /evidence="ECO:0000259|PROSITE:PS50818"
FT REGION 1112..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1127..1154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1154 AA; 123344 MW; 627DF303870D6BD3 CRC64;
MARRKAPATK VDPSAFDQAG ATVVDNPVRT EIEDSYLEYA YSVIHSRALP DARDGLKPVH
RRILFSMHEQ GYRPTHAYVK SSRVVGDCFV RGALVSTPSG LRPIEGIELG EQVLDPGGRP
VPVTAVYENP VSELVRVTWT SGHSMLVTPG QRFRVSAGSG REWVEARDLA GRETVAGAGA
DEVTASDNGY AYVLGVIAAS GSVTAAGELR VESLEAGPVD HVHGWAIGAG LDTRRDKREA
RTPTQRDRHI LTFADAGLLA TRDTVPAVVL ADRAAWLPYL AGLLDGAGHV RRGRGQIAGL
ARPELLRQVW CLLADLGIPA DQWDRSGLRG ITVSGGAAAT LAALLLPWVR SCDKHAGLAH
LAAPAEPSAP VSSTALPVLS TVASVEPVAG DTTYDIQVGS DEHAFVVEGL VVHNCMGKYH
PHGDTAIYDA MVRLAQDFSL NAPLVDGHGN FGSPDDGPAA SRYTEARMSN EAMLLVGELG
EDTVDFRPNY DGSLLEPVVL PAAFPNLLVN GTSGIAVGMA TNMIPHNLGE VVAAARYLIT
HPEADLDKLM EFIPGPDLPT GGMLLGLDEV RKAYETGRGV VRMRAKVEIG HLEGSRRQAI
TVTELPYQVG SEKIIEKITE EVNKSKRLTG IADVKDLTDR ENGTRLVIEC KVGVNPQALL
ADLYRLTPME QSFGINNLVL VEGQPRTLGL KALLEVFLKH RYEVVTRRTR HRKRKREERL
HLVEGLLLAL VDIDKVIRLI RGSDDAAAAK AGLMSRFTLS EVQATYILDT PLRRLTKFDK
LELEDEQEKL RGEIEELAKI LDDDKVLRRV VSTELGKVAR DLTAERRTSL IDGDLKEVLA
ASKPAGPLEV ADDPCQVVLS ATGLVARTAA ESEEASEGRT RKGRARHDAV AALVHSTARG
QVLLVTNRGR AVKTDVLPLP VLPEQSGTVS VSGGMAASEL VSLEKGERVI GIAPLGDQAA
GSPGLALGTR QGVVKVCAPE WPVRSDEFEV ITLKDGDEVI GATWLTDGSE TLAFVTGDAS
LLRYAASLVR PQGLKGGGMA GINVPADGKA LFFGAIRIDD PDHGEPQVVT STGQSVKVTP
FAEYPAKGRA TGGVRAHRFL KGETGLVLAW IGPRPAGSSR TGSAVELPDP DPRRDGSGHA
HPGPDVIGHL VERA
//
