ID A0A1H9YT77_9BACT Unreviewed; 399 AA.
AC A0A1H9YT77;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Thiolase, C-terminal domain {ECO:0000313|EMBL:SES72361.1};
GN ORFNames=SAMN04487998_0082 {ECO:0000313|EMBL:SES72361.1};
OS Hymenobacter actinosclerus.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC Hymenobacter.
OX NCBI_TaxID=82805 {ECO:0000313|EMBL:SES72361.1, ECO:0000313|Proteomes:UP000198697};
RN [1] {ECO:0000313|Proteomes:UP000198697}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15310 {ECO:0000313|Proteomes:UP000198697};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FOHS01000001; SES72361.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9YT77; -.
DR STRING; 82805.SAMN04487998_0082; -.
DR OrthoDB; 9764892at2; -.
DR Proteomes; UP000198697; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF2; 3-OXOADIPYL-COA_3-OXO-5,6-DEHYDROSUBERYL-COA THIOLASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000198697};
KW Transferase {ECO:0000256|RuleBase:RU003557}.
FT DOMAIN 5..268
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 275..397
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 90
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 354
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 385
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 399 AA; 42654 MW; 11949894E0AADBFD CRC64;
MPTAYIVDAV RTPIGKFGGA LSSVRPDDMA AHVLRELLRR NPTLDPTAIE DVILGAANQA
GEDNRNVGRM AALLAGLPVT VPGTTVNRLC ASGLQSIMDA SRAIRAGEGD VYLAGGTESM
TRAPFVMAKS TAAFDRDFTA HDTTLGWRFV NPKLSKLHHP YAMGETAENV ARQYNVSRAD
QDQFAFDSQR KYQRALEKGR FRNEIVPVFI PNPKGHAALF DQDEHPRLST LEKLGTLRPA
FQVDGSVTAG NSAGINDGAA ALLLVSEEAL KKYDLKPMAR VVASAVTGVD PAYMGIGPIS
ATRKVLERAG LSIDDIDLFE LNEAFAAQAL ASMRELGIDP AKVNVNGGSI AIGHPLGASG
ARITATLLHE MQRRDNVRYG LATMCVGVGQ GAAIIYEKM
//
