ID A0A1H9YYY6_9GAMM Unreviewed; 359 AA.
AC A0A1H9YYY6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Serine protease DegS {ECO:0000313|EMBL:SES74416.1};
GN ORFNames=SAMN02583745_00425 {ECO:0000313|EMBL:SES74416.1};
OS Thorsellia anophelis DSM 18579.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Thorselliaceae; Thorsellia.
OX NCBI_TaxID=1123402 {ECO:0000313|EMBL:SES74416.1, ECO:0000313|Proteomes:UP000242642};
RN [1] {ECO:0000313|Proteomes:UP000242642}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18579 {ECO:0000313|Proteomes:UP000242642};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S1C family.
CC {ECO:0000256|ARBA:ARBA00010541}.
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DR EMBL; FOHV01000002; SES74416.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9YYY6; -.
DR STRING; 1123402.SAMN02583745_00425; -.
DR OrthoDB; 9758917at2; -.
DR Proteomes; UP000242642; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00987; PDZ_serine_protease; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011783; Pept_S1C_DegS.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001940; Peptidase_S1C.
DR NCBIfam; TIGR02038; protease_degS; 1.
DR PANTHER; PTHR22939:SF101; PERIPLASMIC PH-DEPENDENT SERINE ENDOPROTEASE DEGQ; 1.
DR PANTHER; PTHR22939; SERINE PROTEASE FAMILY S1C HTRA-RELATED; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:SES74416.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000242642};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 5..23
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 252..314
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT ACT_SITE 100
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR611783-1"
FT ACT_SITE 130
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR611783-1"
FT ACT_SITE 204
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR611783-1"
FT BINDING 187
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR611783-2"
FT BINDING 353
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR611783-2"
SQ SEQUENCE 359 AA; 38123 MW; A14024118B6903D6 CRC64;
MLIKLLKAIV LGAIVGILMI WLFPQIRTKH PEIDVLPTTD NVVQVAPISF HEAVNIAAPT
VVYVYNRGVG DENDKEQLGI RTLGSGVVMR SDGYILTNMH VISGAEQIVV SLQNGSTFEA
ELVGADDLTD LAVLKIDAID LLAIPVNLER KTRVGDVVLA IGNPYNLGVS ITQGIISATG
RISLSLSGRQ NFLQTDAAIN HGNSGGALVN SLGELVGINT LSFDKNEDGT PTTGGLNFAI
PTELAIKVMN KIIKDGRVIR GYFGIKGGDV KMTSTDGVEE ITGIYVSALD ETGPAAKAGI
RVGDVLIKVN NLSVLSTLDA LDKVAEIAPG TIIPVVLIRD EYAIELQLTV GKYPEKESF
//
