ID   A0A1I0AHA8_9BACL        Unreviewed;       741 AA.
AC   A0A1I0AHA8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=Putative drug exporter of the RND superfamily {ECO:0000313|EMBL:SES93552.1};
GN   ORFNames=SAMN03159358_0331 {ECO:0000313|EMBL:SES93552.1};
OS   Paenibacillus sp. NFR01.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=1566279 {ECO:0000313|EMBL:SES93552.1, ECO:0000313|Proteomes:UP000198735};
RN   [1] {ECO:0000313|EMBL:SES93552.1, ECO:0000313|Proteomes:UP000198735}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NFR01 {ECO:0000313|EMBL:SES93552.1,
RC   ECO:0000313|Proteomes:UP000198735};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR   EMBL; FOIK01000001; SES93552.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I0AHA8; -.
DR   STRING; 1566279.SAMN03159358_0331; -.
DR   OrthoDB; 2365435at2; -.
DR   Proteomes; UP000198735; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198735};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        196..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        221..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        251..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        294..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        330..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        394..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        559..576
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        583..607
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        619..641
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        662..683
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        689..716
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          256..351
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   DOMAIN          563..714
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   741 AA;  79448 MW;  DAD4E0811315E46C CRC64;
     MSGYGKWVAG SKTKWITLGV WIAVVAVLSL VWPSVNSQVV NNAQNLPDSA PSVQAQAVAE
     REFPSGSGVP ALLVWHRDGG LTNDDLVHIT ALYGQLEQQP LEHQTFVPPL AQLPPQALQA
     SLSEDRSTIV TPVLFDKSAG SEELGDAVTV LKDRVKAVTG SDPSSAPATG SELSLRVSGP
     VGISIDATGL FKDADVALLM ATVVLVLVFL LLIYRSPILA LIPLFAVGFA YLAVSPVLGK
     MAQEGWITVD SQAVSIMTVL LFGAGTDYCL FLISRFRQLL KQEESKGRAL LNAITQASGA
     IAMSGFTVVL ALFALLLAKY GAYHRFAVPF SLSILIMGVA SLTLVPALLA IFGRASFFPF
     IPRTPEMEAA RAKAKGKPVP PAKHLRKKGV GHLVVTRPWA IVGITAILLG VLASFSSEIK
     FTYDLLSSFP KDMESREGFE QIGEQFSPGE LAPVKLMVDT QGKVNGDDIK VVLGGLSYVD
     TVSDPQKGAV NPNILGFDLE LKMNPYSLEA MKHIPMLQDT VEHALLDEGV QNAQDGVWIS
     GQTATQHDTK EQGERDTDTI IPVVIAMITV LLLIYLRSVT ATLYLVATVI LSFFSALGLG
     WIIIHYILGT DAIQGSIPLY SFVFLVALGE DYNIFMISNI WKKRKTMPLK QAIREGVNET
     GGVITSAGII LAGTFAVLAS LPIQVLVQFG IITAIGVLLD TFIVRPFLVP AITVLFGKRA
     FWPGKHTEIA DAAPEAADGQ P
//