ID A0A1I0CDY1_9CLOT Unreviewed; 729 AA.
AC A0A1I0CDY1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=DNA gyrase subunit A {ECO:0000313|EMBL:SET17777.1};
GN ORFNames=SAMN05660297_01619 {ECO:0000313|EMBL:SET17777.1};
OS Natronincola peptidivorans.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Natronincola.
OX NCBI_TaxID=426128 {ECO:0000313|EMBL:SET17777.1, ECO:0000313|Proteomes:UP000199568};
RN [1] {ECO:0000313|EMBL:SET17777.1, ECO:0000313|Proteomes:UP000199568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18979 {ECO:0000313|EMBL:SET17777.1,
RC ECO:0000313|Proteomes:UP000199568};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
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DR EMBL; FOHU01000005; SET17777.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I0CDY1; -.
DR STRING; 426128.SAMN05660297_01619; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000199568; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR PANTHER; PTHR43493:SF1; DNA TOPOISOMERASE 4 SUBUNIT A; 1.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000199568};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 8..456
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT COILED 428..455
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 729 AA; 83199 MW; 818BBD049A2001E5 CRC64;
MQSKLTQLNV IETLEKNYMP YSMSVIISRA LPEIDGLKPS HRKLLYTMFK MGLLKGAKTK
SANIVGQTMK LNPHGDGAIY ETMVRLTRGN EALLHPLIDS KGNFGKNYSK EMAYAAPRYT
EAKLEEICQE LFKDIHKDTV DFVPNYDNTM QEPKLLPTTF PNILVNPNMG IAVGMASSIC
SFNLQEVCKA TVEFLKNEEV DISQYLKGPD FSSGGQFILN KSEFKGIYNT GRGTFHLRGK
YRYDKVNNCI EIYEIPYTTT TEAIIEKIIE LVKAGKIKEI NDIRDETDKE GLKITIDLKR
NTDAEHLMNR LYKMTTLQDT FSCNFNLLIN GNPRVLGVKE IIKEWTVFRI RCIKRQLAFD
VKQKSERLHL LKGLEKILLD IDKAVKIVKD TKKDKEVIPN LMKGFEVDEI QAEFIADIKL
RNFNQEYILN KTKDIQVLQK EIKNLEDTLK SDNKINRLII KELEAVSEKY GKPRKTEVIE
EQHVEVVSEE VLIEDYKVKY FLTKESYLKK VTLASLRSSS NGHKLKDDDV IIQEIEGNNK
SDLLLFSSKQ VVYKIRGYEL EDKKTSSLGD YLMNLLSLGD DEKIIYMAAT DDYSGHMLFF
YKNGKCAKIP LESYQTKTNR KQLANAYSNE SPLVYIEHIT EDKELVAVSS IKKVLVFNTE
GINAKTTRSS IGIQVLKSKN NSTLTNIIAP ENVSFADMDY YKGKVPAIGT FLKKEDSLQK
AGPIQTSML
//
