ID A0A1I0E0A8_9BACL Unreviewed; 932 AA.
AC A0A1I0E0A8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN03159358_1526 {ECO:0000313|EMBL:SET38432.1};
OS Paenibacillus sp. NFR01.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1566279 {ECO:0000313|EMBL:SET38432.1, ECO:0000313|Proteomes:UP000198735};
RN [1] {ECO:0000313|EMBL:SET38432.1, ECO:0000313|Proteomes:UP000198735}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NFR01 {ECO:0000313|EMBL:SET38432.1,
RC ECO:0000313|Proteomes:UP000198735};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FOIK01000001; SET38432.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I0E0A8; -.
DR STRING; 1566279.SAMN03159358_1526; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000198735; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000198735}.
FT DOMAIN 685..701
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 611..618
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 932 AA; 102374 MW; C6CE573C0976AD25 CRC64;
MAKYTPMIEQ YLKVKEGAKD AFLFFRLGDF YEMFFEDALL ASKELEITLT GREGGGDERI
PMCGVPYHAA EGYIQRLIEK GYKVAICEQL DDPAVTKGMV RRDIVRVVTP GTVMDGKIIN
DKANNYLVCV TETEGMMALA ACDLTTGELY VTSVLSGSEW LRDEIGIYEP AEIIGDPALL
ELLQRDNPLP AKPVVYTPWD KREEELARRQ FGEAVWVRLE KERSQCVALL ISYLSETQRR
SLGQLSQISP YEPGNYMILD PFTRRNLELT ETVRERAKKG SLLWLLDRTE TSMGGRLLRR
RIDKPLLSRT LIEQRLEAVD YLYNQFIVRE DLRTALKEIY DLERLVGRVA YGSANGRDLN
AMKLSLAQIP ALKELCLTSG SATLREIGAA MDECAEIRDD IERAVVEDAP VSIRDGGIIR
PGYHERLDEL HEANSSGKRW IAELEAKERA YTGIKSLKIG YNKVFGYYIE VTRSNLAALP
EGRYERKQTL ANAERFVTPE LKEKEALILE AEDKMTDLEY ALFTELRERI AGQIARLQGL
AEKIAEIDVY QCLAAVSAEH RFVRPKLSDG YDLKVEGGRH PVVEAVLKDA AFIENGSLLS
KDEGNILLIT GPNMAGKSTY MRQVALICIL AQIGCFVPAA SAEIPLIDRI FTRIGAADDL
IGGQSTFMVE MADIQVMTEK ATARSLIIID ELGRGTSTSE GMAIAQAVIE YVHDTIGCKA
LVSTHFHELA HLEDSLKGLR NYSMAVQESG DKVNFLRKLV PGAADSSYGI YCARLAGLPE
GIIDRAYGLL QSIEQAAPGI AAYAAVAVTA EGATEAAAPQ GSAAQAIAAA APQRQALAES
GNPAGYITLG DAAGDSAGDQ REVVQLSIFG EEETPKSGRK ADAARAAAPA EAKPNPLLKE
LVAAVQDADL MNMTPLQAMA LLNDLKQKAR GL
//
