ID   A0A1I0EC30_9BACI        Unreviewed;       942 AA.
AC   A0A1I0EC30;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=DNA polymerase I {ECO:0000256|ARBA:ARBA00020311};
GN   ORFNames=SAMN05216389_11133 {ECO:0000313|EMBL:SET42708.1};
OS   Oceanobacillus limi.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX   NCBI_TaxID=930131 {ECO:0000313|EMBL:SET42708.1, ECO:0000313|Proteomes:UP000198618};
RN   [1] {ECO:0000313|EMBL:SET42708.1, ECO:0000313|Proteomes:UP000198618}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBRC-M 10780 {ECO:0000313|EMBL:SET42708.1,
RC   ECO:0000313|Proteomes:UP000198618};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC       {ECO:0000256|ARBA:ARBA00007705}.
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DR   EMBL; FOHE01000011; SET42708.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I0EC30; -.
DR   STRING; 930131.SAMN05216389_11133; -.
DR   Proteomes; UP000198618; Unassembled WGS sequence.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR   Gene3D; 3.30.70.370; -; 2.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR002298; DNA_polymerase_A.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR   PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR   Pfam; PF00476; DNA_pol_A; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   PRINTS; PR00868; DNAPOLI.
DR   SMART; SM00482; POLAc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198618}.
FT   DOMAIN          626..896
FT                   /note="DNA-directed DNA polymerase family A palm"
FT                   /evidence="ECO:0000259|SMART:SM00482"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          417..469
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..31
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   942 AA;  109244 MW;  3A26D601780BFFB4 CRC64;
     MTEIKLSLNP KATESTDAKS RIKDAEKRKA SANETMDEAW ARILSMKLSD KDRRLVKLAQ
     QAFNDGNIGR LKDGKFSKIE AVQMGRQVDE ENKRVMREER MQDTLANKPS NYFVITDDSD
     LPAMVERLRQ EVRQQQDDDW FRKVFRLFND THIRKKLTSR GVDLPEITSF TEWDTETSGT
     DTMIDMSGGY SFWLPILNEG YYVAYGHLTD DPQCSRSAAL GAIRKFIEHP SQAKAFHNTP
     FDYSMFLNDG MNPKGFRYDS LDAQFILNEH EESNGLKPLT TKYKSLIGTE HLDDYTFEDL
     FGNGSPMVYP PEVVGIYAIK DVEKGWLLTK WQIEMMLAKD DLYKPYFEIR QYLYEVNTTI
     ERTGFVVNTE RLAELEAEYE PKLQEAINAI TETYGINDEF LRKMDRKINA NKIDKWCESQ
     RKRIVRKKEQ IEKKRSKIAE LQSEAKTHLK SYQNERDMLE KYERELSELD EPTIDNAPIF
     TEEFNLNSND HLAYLIYDVL KIEDKTKLFD KKKERSTSKD VLELYFKEEE SLKPLSEYSK
     LSTLLGTFIK KIPKAFDYDG RVHTSLSTVS TGRYGSKGYT GKPNELWRNN IDDNNFLDHM
     AVLVEAEKKS KKGTNLQNIP SRTEEGQKVR MAFEPPKYHT FFGSDLSSIE PRIQAHRMAT
     EFDDEIFAEM YRKGLDPYVE FAAILFDVPK EVCTEAYYKS VKGTDKAVPA YRKAMKQMFL
     AIGYGQAFDM FYKGVIPFGV GEEQAQVAYD KFDEILPGFK GMVEATFEHL RKHGWTATIF
     GQKRRFPGYV EKYKRLCTLM KLAGISDKND PELGKKANRL RRKGSKDSDL VGEFWDLMRF
     TGGCERAAFN HTIQGSGANI LQMCMIRAYY ECTLGRGWEF SLTLHDELKF AVPNEQVTKE
     SAELLDDIMK NTYNLVLPLD CDTVIEPRWM EEYSPDEWFS NK
//