ID A0A1I0H467_THASX Unreviewed; 543 AA.
AC A0A1I0H467;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SAMN05660429_02675 {ECO:0000313|EMBL:SET78315.1};
OS Thalassotalea agarivorans (Thalassomonas agarivorans).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Colwelliaceae; Thalassotalea.
OX NCBI_TaxID=349064 {ECO:0000313|EMBL:SET78315.1, ECO:0000313|Proteomes:UP000199308};
RN [1] {ECO:0000313|EMBL:SET78315.1, ECO:0000313|Proteomes:UP000199308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19706 {ECO:0000313|EMBL:SET78315.1,
RC ECO:0000313|Proteomes:UP000199308};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; FOHK01000014; SET78315.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I0H467; -.
DR STRING; 349064.SAMN05660429_02675; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000199308; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SET78315.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199308};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 7..223
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 543 AA; 62173 MW; 5A6C2233BCC72B00 CRC64;
MKFKADQTTQ KLRGGYYTPQ NLADYVTKWV ITSKTNSILE PSCGDGTFID SISVNTERKD
INIKAFELFD TEAKKSLKKC SKYGFENYDV HEGDFLTWAN SAIRENNTTF SGILGNPPFI
RYQFLEKDFQ EQAELIFKQL NLKFTKHTNA WVPFILASIK LLEAGGRFGM VIPSEIIHVM
HAQSLRTFLG EQCSKLVIID PQEIWFKDTL QGAVILFAQK KNDINEVSQG VGIKHVKGFE
FLKTDPETIF DETSGINGET VSGKWTKALL DKSELDLINK IKSHPNVYKF TEVADVDVGI
VTGANKFFLV EHSIVDQYGL HDYAHPMFGK SQHCKGIVYD QQQHTSNEEN KLPTNFLYIE
DEFDTLPSNV QEYIKLGESE GLHERYKCRI RKPWYKVPSV YSRSLGMLKR SHDTPRLIFN
EIEAYTTDTA YRITSLGTEP SLLACSFLNP LTAIFAELEG RYYGGGVLEL VPSEIEKLYI
PLPENIEFDI RNIDQQIRNG NIREVLQAQG RLIFGALGFT QEESDLLVLI WEKLKHRRQR
KDH
//
