ID A0A1I0HWS4_9ACTN Unreviewed; 845 AA.
AC A0A1I0HWS4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN05421811_104547 {ECO:0000313|EMBL:SET88515.1};
OS Nonomuraea wenchangensis.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Nonomuraea.
OX NCBI_TaxID=568860 {ECO:0000313|EMBL:SET88515.1, ECO:0000313|Proteomes:UP000199361};
RN [1] {ECO:0000313|EMBL:SET88515.1, ECO:0000313|Proteomes:UP000199361}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.5598 {ECO:0000313|EMBL:SET88515.1,
RC ECO:0000313|Proteomes:UP000199361};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; FOHX01000004; SET88515.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I0HWS4; -.
DR STRING; 568860.SAMN05421811_104547; -.
DR OrthoDB; 9806130at2; -.
DR Proteomes; UP000199361; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SET88515.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000199361};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 378..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 627..840
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 845 AA; 90478 MW; C4C204A4A057452F CRC64;
MRGRLRVYLG AAPGVGKTYA MLSEGRRGLE RGRDVVVGLV ETHGRPRTAA LLEGMEIVPR
RTVRYRGATF TELDVPAVIE RRPKVALIDE LAHTNAPGSG NVKRWQDIDE ILDAGIDVIS
TVNIQHLESL NDVVQGITGV PQRETVPDEV VRRADQIELV DMSPEALRRR MAHGNVYAPE
KVSAAMSNYF RVGNLTALRE LALLWAAGKV DDQLDRYRAD HGIADTWETR ERVVVALTGG
PEGDTLVRRA ARIAARTKGA DLLAVHVVSG DGLAGVDPAS LARQRTLVES MGGTYHQVVG
GDVPRALIDF ARGVNATQLV LGASRRGRFA QILARGVGVE TISLSGSIDV HLVTHEEAKR
GRRRPERDRA ALTRERRMAG WAVAMAGLPA LTAVLAPFRD VLQLPSEILL FLLLVVVVAL
IGGMWPAIAA AVGGSLLLNW FFTPPVGFIT IAHPENLLAL IVFVLVAAAV STIVDVAARR
TRQAAHATAE AEVLSTLAGH VLRGDAALPS LLGRLRETFG LDSVTLLERV GDPTPDDQAD
PRAWRIIATS GAAPCTAPAT ADTDVVISDE LVLAARGQLL NAGDRRVLEA FAAEAAVALR
QERLEEEAEL ARPLAEADKM RTALLAAVSH DLRTPLSAAK AAVESLRGDE VEWSEEDREE
LLATADESLT RLGRLVDNLL DMSRLQAGVL GLALQPVALE EVVPRAVDDL GPLCDHVEND
VPVELPDVVA DPALLERVLA NLIANAVRYS PPGHKVLVTA GRYGDQVEIR VADRGPGIRP
EDHERVFLPF QRLGDRDNGT GVGLGLALSR GLTEAMGGTL IPEETPGGGL TMIVNLPVHT
GAAAP
//
