ID   A0A1I0I2E6_9BACT        Unreviewed;       518 AA.
AC   A0A1I0I2E6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=hydroxymethylglutaryl-CoA reductase (NADPH) {ECO:0000256|ARBA:ARBA00012999};
DE            EC=1.1.1.34 {ECO:0000256|ARBA:ARBA00012999};
GN   ORFNames=SAMN04487998_3097 {ECO:0000313|EMBL:SET90645.1};
OS   Hymenobacter actinosclerus.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC   Hymenobacter.
OX   NCBI_TaxID=82805 {ECO:0000313|EMBL:SET90645.1, ECO:0000313|Proteomes:UP000198697};
RN   [1] {ECO:0000313|Proteomes:UP000198697}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15310 {ECO:0000313|Proteomes:UP000198697};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC       {ECO:0000256|ARBA:ARBA00007661}.
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DR   EMBL; FOHS01000004; SET90645.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I0I2E6; -.
DR   STRING; 82805.SAMN04487998_3097; -.
DR   OrthoDB; 9794902at2; -.
DR   Proteomes; UP000198697; Unassembled WGS sequence.
DR   GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:UniProtKB-EC.
DR   GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd00643; HMG-CoA_reductase_classI; 1.
DR   Gene3D; 3.30.70.420; Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain; 1.
DR   InterPro; IPR002202; HMG_CoA_Rdtase.
DR   InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR   InterPro; IPR004554; HMG_CoA_Rdtase_eu_arc.
DR   InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR   InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR   PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR   PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR   Pfam; PF00368; HMG-CoA_red; 1.
DR   PRINTS; PR00071; HMGCOARDTASE.
DR   SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR   SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR   PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198697}.
SQ   SEQUENCE   518 AA;  56448 MW;  22BB9105B8C50CA6 CRC64;
     MVFTPSPLLL KLLYTRGSLR NTPEGVAFSI KNRLDTVRIT RIDHVQIDDR RLGVGEIAID
     LGEGDIRPAV VFNADSAGFT LPVGQSATFY LATDQLTEGL HTIQVQFAAD PFGDLNVEVE
     DSITLTPDNR PRIPRSSQDD YSDEAIRKRQ DFAEEFTGQQ FEHLKQYSFD AHALQGNCEH
     FTGIAQIPVG LAGPLHVNGE HAQGDFLIPL ATTEGTLVAS YNRGIQLLNL SGGVKCTVIG
     DAMQRAPVFV FDDARGARDF GRWVEEEIAR IRPEAESTSS IAKLQYIDTY LSNKFAFLRF
     NYSTGDAAGQ NMVGRATFAA CSWILENYKG APIRHFYLES NFATDKKASQ INVMRTRGKR
     VVAEAVIPRN LLQQRMRVTP EQLAYHGQVS NVGAFMSGAN NNGAHSANGI TALFIATGQD
     VANVSESSAG VFYSEITPEK DLYISITIPS LIVATHGGGT GLATQNEYLR MLGCVGRGTV
     NKFAEIVAGV VLAGELSLGS AISSSDWVSS HEQYGRNR
//