ID A0A1I0J7T8_9BACT Unreviewed; 965 AA.
AC A0A1I0J7T8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN ORFNames=SAMN04487998_3696 {ECO:0000313|EMBL:SEU05972.1};
OS Hymenobacter actinosclerus.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC Hymenobacter.
OX NCBI_TaxID=82805 {ECO:0000313|EMBL:SEU05972.1, ECO:0000313|Proteomes:UP000198697};
RN [1] {ECO:0000313|Proteomes:UP000198697}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15310 {ECO:0000313|Proteomes:UP000198697};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
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DR EMBL; FOHS01000007; SEU05972.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I0J7T8; -.
DR STRING; 82805.SAMN04487998_3696; -.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000198697; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 3.30.190.20; -; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF4; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000198697};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 278..610
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 617..961
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 965 AA; 106893 MW; E7B0ADFEB945AA5B CRC64;
MADNSALQLA APAADPIDQL DPREFILIKN ARVHNLKNLS VALPRNKFIV VTGLSGSGKS
SLAFDTLYAE GQRMYVESLS SYARQFLGRM DKPDVDYIRG ISPAIAIEQK VSIKNNRSTV
GTSTEIYDYL KLLFARVGRT YSPISGEQVR KDNVADVVDY LMRLPEGTRV MLLAPLLRAE
DGRPLSKELD LLLQKGYSRV VVNGETAFIE DLLAEGQPEP TDGDIFIMID RAVIIPQDED
LAFRLADSVQ TAFFEGHGSL VASYQLSVVS ADDQQTGLTT DNQPLTTQRT FSDKFELDGL
AFEEPSVNFF SFNNPYGACQ TCEGFGSVLG IDEDLVIPDK SLTVYEGAIA PWRTDKQSEW
LKPLIKNGIR FDFPIHRPYN ELTEKERALL WKGNKYFDGL DDYFKWVATQ THKIQYRVLQ
SRYRGRTTCP DCRGSRLRKD AQYVKIEGKS ITDLVLLPVS EALTYFAELD LPEHEAKVAE
RLVTEITNRL GYLHRVGLGY LTLNRLSSTL SGGESQRISL ATSLGSALVG SMYILDEPSI
GLHPQDAEQL IGVLRSLQQL GNTVIVVEHE DKMMEQADQI IDIGPEAGSG GGILQFQGTY
AEVLTSDTYT GQYLSGRREV AVPKTRRPWR NALELTGARE NNLKNVSVKF PLNVMTVVTG
VSGSGKSTLV KRILAPALLK QLGGGAGEST GKFDRLTGAA GQVTHVEFVD QNPIGKSSRS
NPVTYVKAYD TIRSLFADQP LAKARGFKPS HFSFNVEGGR CEVCQGEGQV KIEMQFMADI
FLTCEACEGR KFKQDVLDVQ YQNQSINDVL ELTIEDSLDF FKDQPKIIER LKPLDDVGLG
YIRLGQSANT LSGGEAQRVK LASFLTKGNT LQNDKILFIF DEPSTGLHFH DINKLMLALN
ALVEQGNSVL IIEHNMDIIK CADWLIDLGP EGGLNGGHLL FEGTPEQFIK LKDTNSTARF
LAEKL
//
