ID   A0A1I0LG54_9ACTN        Unreviewed;       388 AA.
AC   A0A1I0LG54;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   SubName: Full=Two-component system, NarL family, sensor histidine kinase DesK {ECO:0000313|EMBL:SEU39087.1};
GN   ORFNames=SAMN05421811_116130 {ECO:0000313|EMBL:SEU39087.1};
OS   Nonomuraea wenchangensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=568860 {ECO:0000313|EMBL:SEU39087.1, ECO:0000313|Proteomes:UP000199361};
RN   [1] {ECO:0000313|EMBL:SEU39087.1, ECO:0000313|Proteomes:UP000199361}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.5598 {ECO:0000313|EMBL:SEU39087.1,
RC   ECO:0000313|Proteomes:UP000199361};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FOHX01000016; SEU39087.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I0LG54; -.
DR   STRING; 568860.SAMN05421811_116130; -.
DR   OrthoDB; 5241784at2; -.
DR   Proteomes; UP000199361; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR   Gene3D; 1.20.5.1930; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR   PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR   PANTHER; PTHR24421:SF63; SENSOR HISTIDINE KINASE DESK; 1.
DR   Pfam; PF07730; HisKA_3; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SEU39087.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199361};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   TRANSMEM        12..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        41..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        71..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        123..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        153..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          198..264
FT                   /note="Signal transduction histidine kinase subgroup 3
FT                   dimerisation and phosphoacceptor"
FT                   /evidence="ECO:0000259|Pfam:PF07730"
SQ   SEQUENCE   388 AA;  42175 MW;  A187E201C0EFEEF4 CRC64;
     MEALQRARRI TWITLIAGLV MLWAFLALGS VVLFGEGRFP WWRAVPAFAA AVGLTWLAWR
     AIDAVMAGRY PRREIVVSAV LAVIGTAAGG GDPFGWGFLI MVWVYTATLR VSKRTAILQS
     VGAFVVAVAL GLLGVATDAG VSGADLELPE AVVYFGVVYA IWCLTMPPSG RLWLWIWMLA
     EQAHRGREAH TRLALAEERL RFARDLHDLV GHQLSAIAVK TELAKRLSEA DPAAARAELT
     EINTLTRRAL RELREAVRGY RELDLTAELD SVKGVLEAAG VRCEVRLPYR ELPAGLAPVF
     AYAVREAVTN VLKHSTATFC EITIRFTPER AELSVRNNGV ARRQAADPGS GLTGMAERLA
     TVGGAVRARP TEDGEFLLEA VVSLPVDG
//