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Database: UniProt
Entry: A0A1I0M3A7_9GAMM
LinkDB: A0A1I0M3A7_9GAMM
Original site: A0A1I0M3A7_9GAMM 
ID   A0A1I0M3A7_9GAMM        Unreviewed;       355 AA.
AC   A0A1I0M3A7;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   16-JAN-2019, entry version 5.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=SAMN04515660_0014 {ECO:0000313|EMBL:SEV82925.1};
OS   Luteibacter sp. 329MFSha.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Rhodanobacteraceae; Luteibacter.
OX   NCBI_TaxID=1798239 {ECO:0000313|EMBL:SEV82925.1, ECO:0000313|Proteomes:UP000199162};
RN   [1] {ECO:0000313|EMBL:SEV82925.1, ECO:0000313|Proteomes:UP000199162}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=329MFSha {ECO:0000313|EMBL:SEV82925.1,
RC   ECO:0000313|Proteomes:UP000199162};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; FOJE01000001; SEV82925.1; -; Genomic_DNA.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000199162; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR022697; HDH_short.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF036497; HDH_short; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000199162};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR036497-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN       22    141       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      157    353       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
FT   NP_BIND      22     27       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   ACT_SITE    225    225       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR036497-1}.
FT   BINDING      99     99       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     123    123       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     210    210       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR036497-2}.
SQ   SEQUENCE   355 AA;  37128 MW;  47CA80AA258A90DB CRC64;
     MNAVAIAPQA QSAPRTAVVL LGTGVVGRAL LTLLGTPAAR SLRLVGAANS KRQHVLAEGV
     APADVAQHLA RGREGRDNAP LLAALDAAGA DRKVVIDATA CATEASRHAE WLAAGYHVVT
     ANKALAGGHL SGWRALQQAT STGSVYGDAA TVGAGLPVLS TLRRLRHCGD SLLTLEGVFS
     GSLSWLFNQY DGSRPFSALL RDARRLGFTE PDPRSDLSGE DVARKLLIIA RNAGFALGSD
     EVEVESLVPE ALRGVDTATF LGRLEELDEP LRARHAQATA NGKVLRYLAR LNQRGRARVG
     LVEVGPDHPA ARLSGTDNQF ALTTTRYHAT PLVIQGPGAG PEITAQALLG DVLAL
//
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