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Database: UniProt
Entry: A0A1I0MRN7_9GAMM
LinkDB: A0A1I0MRN7_9GAMM
Original site: A0A1I0MRN7_9GAMM 
ID   A0A1I0MRN7_9GAMM        Unreviewed;       789 AA.
AC   A0A1I0MRN7;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   08-MAY-2019, entry version 9.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SEV91295.1};
GN   ORFNames=SAMN04515660_0905 {ECO:0000313|EMBL:SEV91295.1};
OS   Luteibacter sp. 329MFSha.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Rhodanobacteraceae; Luteibacter.
OX   NCBI_TaxID=1798239 {ECO:0000313|EMBL:SEV91295.1, ECO:0000313|Proteomes:UP000199162};
RN   [1] {ECO:0000313|EMBL:SEV91295.1, ECO:0000313|Proteomes:UP000199162}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=329MFSha {ECO:0000313|EMBL:SEV91295.1,
RC   ECO:0000313|Proteomes:UP000199162};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
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DR   EMBL; FOJE01000001; SEV91295.1; -; Genomic_DNA.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000199162; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000199162};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296}.
FT   DOMAIN       10    193       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      196    295       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   789 AA;  84658 MW;  477D3397B1F7173D CRC64;
     MTATPLRIRK AAVLGAGVMG AQIAAHLTNA NVETVLFDLP AKEGPKSGIA LKAIANLAKL
     SPAPLAEKSL GAAIIPANYE DDLAQLADVD LVIEAIAERM DWKLDLYTKI APHVSKTAVL
     ASNTSGLSIN GLAEALPEAL RHRFTGVHFF NPPRYMHLVE LIPTKLTDAT VLEGLEAFLT
     TTLGKGVVYA KDTPNFIGNR IGVFSMLSTM HHTEQFGLGF DTVDALTGPA IGRPKSATFR
     TADVVGLDTL AHVVKTMSDT LPDDPWHAFF QPPAWLKALI EKGALGQKTG AGVYRKAGKD
     IVVLDLQKQD YRVSEQKASD EVSAILAIKD PAEKFAKLRA SSDPQAQFLW AVFRDLFHYT
     AYHLADIADT ARDVDFAIRW GYGWKLGPFE IWQSAGWQQI AGWIAEDIAA GKAMSSAPLP
     AWVTDGRTGV HGKTGSYSAS AKAEKPRSAH PVYARQAFPD PILGETFDKG STVWENDGVR
     LWTSGDDIGV ISFKTKMHTV NDHVLDGIQH AIGLAEQQFR GVVLWQPSEP FSAGADLKGA
     LGLLKEGKLA QFEAMVANFQ ATSMRIKYSL VPVVAAVRGL ALGGGCEFQM HAARTVAALE
     SYIGLVEAGV GLLPAGGGLK ELAVRAAQEN PADPFESLKK VFETVAMAKV SASALEAKSL
     GLLRKDDVVV FNSYEVLHVA KAQARAMAES GYRPPLPARA IPAAGDVSTA TFKASLANLA
     EGYFASPHDI EIASRIADAL SGGKIERGSL VDEAWLLALE RRHFVELAQT EKTQARIAHT
     MTTGKPLRN
//
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