ID A0A1I0NFJ7_9EURY Unreviewed; 645 AA.
AC A0A1I0NFJ7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=dihydrolipoyllysine-residue acetyltransferase {ECO:0000256|ARBA:ARBA00013114};
DE EC=2.3.1.12 {ECO:0000256|ARBA:ARBA00013114};
GN ORFNames=SAMN05216285_1650 {ECO:0000313|EMBL:SEV99799.1};
OS Natrinema salifodinae.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natrinema.
OX NCBI_TaxID=1202768 {ECO:0000313|EMBL:SEV99799.1, ECO:0000313|Proteomes:UP000183275};
RN [1] {ECO:0000313|Proteomes:UP000183275}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.12284 {ECO:0000313|Proteomes:UP000183275};
RA Varghese N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317}.
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DR EMBL; FOIS01000002; SEV99799.1; -; Genomic_DNA.
DR RefSeq; WP_049988652.1; NZ_JROF01000001.1.
DR AlphaFoldDB; A0A1I0NFJ7; -.
DR STRING; 1202768.SAMN05216285_1650; -.
DR eggNOG; arCOG01706; Archaea.
DR eggNOG; arCOG03686; Archaea.
DR OrthoDB; 56234at2157; -.
DR Proteomes; UP000183275; Unassembled WGS sequence.
DR GO; GO:0045254; C:pyruvate dehydrogenase complex; IEA:InterPro.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IEA:InterPro.
DR CDD; cd06849; lipoyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.300.20; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 2.
DR InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR045257; E2/Pdx1.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR003718; OsmC/Ohr_fam.
DR InterPro; IPR036102; OsmC/Ohrsf.
DR InterPro; IPR004167; PSBD.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR23151; DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED; 1.
DR PANTHER; PTHR23151:SF90; DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02817; E3_binding; 2.
DR Pfam; PF02566; OsmC; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF82784; OsmC-like; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 2.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00189; LIPOYL; 1.
DR PROSITE; PS51826; PSBD; 2.
PE 3: Inferred from homology;
KW Lipoyl {ECO:0000256|ARBA:ARBA00022823};
KW Pyruvate {ECO:0000313|EMBL:SEV99799.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000183275};
KW Transferase {ECO:0000313|EMBL:SEV99799.1}.
FT DOMAIN 2..77
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 141..178
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
FT DOMAIN 192..229
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
FT REGION 63..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 645 AA; 67719 MW; 6E910D8F633297B2 CRC64;
MGYIVRMPKL GLEMERGTLL DWAADEGDSV SEGDLIAEVE SEKSVADVEA REDGALRRTY
LEAGESVPPG TPIGIVAPPE SDISGLESEA TADLEANVEL EDGPKTEIEP AADDQAAEPS
AAGGADAETT DGDGASADEI KASPRARERA AALGVDLTTV EGTGYQGSIS EADVERAAKE
ADTGDEDGSE PDASPRARKR AEELGVDLST VEGTGYQGAI SASDVEAAAE SEPAAVDATA
GGAAPRTLDE ERPFDGMRRT IASRLSESYR EAVHVTVHRE ADAEALFAAA DVASDVLETD
VSVQDVLLRA VSATLAEHPG FNATFEDDVH KHWSERNLGI AVDVEQGLIA PVLPDVGEKS
LAEIADERRD LVDRAVSGDY TMDDLQGGTF TVTNLGVLGV ESFDPIINPP QVAILGVDAV
AERPTRGDDD GVEWRRHLPF DLTFDHRVVD GADAARFLET LVGHVAEPWP LLPDAVAEAA
DAADGAGGVA AESESEAAEV DGGPAGADAE TEMPGRSVSA ANPEGMRGRI EAGSFEWSYD
EPESSGGTET GPTPVDVFLG GLASCLSLSA RYQASKRDAA VDEIRVDVDA APEEGSVERI
EATIQIDSDE DDETLERIVD LAERGCHVSQ LLRADLDLNL TWDQL
//
