ID   A0A1I0NX56_9BACT        Unreviewed;      1249 AA.
AC   A0A1I0NX56;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Cu(I)/Ag(I) efflux system membrane protein CusA/SilA {ECO:0000313|EMBL:SEW06104.1};
GN   ORFNames=SAMN05216290_1526 {ECO:0000313|EMBL:SEW06104.1};
OS   Roseivirga pacifica.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Roseivirgaceae;
OC   Roseivirga.
OX   NCBI_TaxID=1267423 {ECO:0000313|EMBL:SEW06104.1, ECO:0000313|Proteomes:UP000199437};
RN   [1] {ECO:0000313|Proteomes:UP000199437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.12402 {ECO:0000313|Proteomes:UP000199437};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FOIR01000001; SEW06104.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I0NX56; -.
DR   STRING; 1267423.SAMN05216290_1526; -.
DR   OrthoDB; 636130at2; -.
DR   Proteomes; UP000199437; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF19; CATION EFFLUX SYSTEM PROTEIN CUSA; 1.
DR   Pfam; PF00873; ACR_tran; 3.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199437};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        365..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        389..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        414..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        498..520
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        540..569
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        609..631
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        643..662
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1054..1073
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1080..1101
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1121..1141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1179..1198
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1210..1235
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1249 AA;  137655 MW;  5A80ED156FFFE24B CRC64;
     MINTLIKFFL ENRLVTFLLI VLLVGWGLVT APFSWNTGLP KDPVPVDAIP DIGENQQIVF
     TEWAGQSPQD IEDQITYPLT SSLLGIPGVK TIRSSSIFGV SSIYIIFNED VEFYWSRSRV
     LEKLNALPKG LLPDGVQPAL GPDATALGQI FWYTIEGRDE NGQPTGGWDP QEIRTVQDYN
     VRYGLAAAEG VSEVASVGGF VKEYQVDIDP TAMEGYGVTL TEIVKAVKES NLDVGAKTLE
     VNQAEYLVRG LGYIKNLEDL ENAVVKANEN TPILLKDVAF VNLGPASRRG ALDKSGAEAV
     GGVVVARYGA NPLEVIENVK AKIEAISSGL PSKILSDGTK SQLTIVPFYD RTQLIKETIG
     TLEEALTLEI IITIVVVLVM LLNLRASLLI SSLLPIAVLM CFVAMRYLGV DANIVALSGI
     AIAIGTMVDV GIVLTENISR HMEEQKSKTL LDTIYTASKE VAPAIITAVM TTVVSFVPVF
     TLQASEGKLF RPLAYTKTFA LIAAILVALL ILPTLAYWFF GFQPKSKWSK IAIHTGVSIF
     GIWVLVLGHY LAAFMLLGYG LVGLVKALVT NTQQLLKHAE ITIALIGISI LLSQSWLPLG
     VQSTAFTNWL FVALVIATTL GIFSLFIRFY PRILNWCLSN RKVFLIIPTF VILFGVTIWQ
     GFDRVFGFIP SAFGDSIRTQ KTYSKLAHSL PGIGKEFMPS LGEGAFLLMP TSMPHAGIEQ
     NRQVLRMLDM AVTAIPEISS VVGKMGRTES ALDPAPISMY ENVINYKSEY KTDENGHRIR
     FKYKNDAFVR DAKGELIPDK NGRYFRQWRD HIQSPDDIWN EIVKATKLPG VTSAPKLQPI
     ETRLVMLQTG MRAPMGIKVK GPDLKTIESF GLELEEILKE VSSVKAEAVF AERIVGKPYL
     LLELKRDALA RYGLSIAQVQ QYLQVAIGGM NLSTTVEGRE RYPIRVRYPR ELRDDPEALK
     NILIPTSNGK NIPLGEVAQI EYTQGPQMIK SEDTFLVGYV IFDKRDGFAE AQVVEAVQDL
     IDQKVEAGEL NIPAGVSFDF AGNYQNQIRA EQRLSLVIPI VLVIIFLILY FQFKSVPVSL
     MVFSGVAVAF GGGFIMLWLY GQEGFLNFDL FGTNMRELFQ VHPVNLSVAV WVGFIALFGI
     ATDDGVLMAT YLDQSFEKSQ SLSKAEIKQR VIEAGKKRVR PCLMTTATTL LALLPILTST
     GRGSDVMIPM AIPSFGGMAI ALITLFVVPV LYSYYKEFQL KYKQKGGLL
//