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Database: UniProt
Entry: A0A1I0R2E4_9FIRM
LinkDB: A0A1I0R2E4_9FIRM
Original site: A0A1I0R2E4_9FIRM 
ID   A0A1I0R2E4_9FIRM        Unreviewed;       685 AA.
AC   A0A1I0R2E4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   10-APR-2019, entry version 5.
DE   RecName: Full=Ferrous iron transport protein B {ECO:0000256|RuleBase:RU362098};
GN   ORFNames=SAMN05421659_11192 {ECO:0000313|EMBL:SEW34626.1};
OS   [Clostridium] fimetarium.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae.
OX   NCBI_TaxID=99656 {ECO:0000313|EMBL:SEW34626.1, ECO:0000313|Proteomes:UP000199701};
RN   [1] {ECO:0000313|EMBL:SEW34626.1, ECO:0000313|Proteomes:UP000199701}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 9179 {ECO:0000313|EMBL:SEW34626.1,
RC   ECO:0000313|Proteomes:UP000199701};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake
CC       system. {ECO:0000256|RuleBase:RU362098}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-
CC       like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000256|RuleBase:RU362098}.
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DR   EMBL; FOJI01000011; SEW34626.1; -; Genomic_DNA.
DR   BioCyc; GCF_900111235:BMY18_RS14070-MONOMER; -.
DR   Proteomes; UP000199701; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR041069; FeoB_Cyto.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR006073; GTP_binding_domain.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF17910; FeoB_Cyto; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00437; feoB; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000199701};
KW   GTP-binding {ECO:0000256|RuleBase:RU362098};
KW   Ion transport {ECO:0000256|RuleBase:RU362098};
KW   Iron {ECO:0000256|RuleBase:RU362098};
KW   Iron transport {ECO:0000256|RuleBase:RU362098};
KW   Membrane {ECO:0000256|RuleBase:RU362098};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199701};
KW   Transmembrane {ECO:0000256|RuleBase:RU362098};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362098};
KW   Transport {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    295    315       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    355    379       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    399    423       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    465    485       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    523    544       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    564    587       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    599    621       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    627    646       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    658    680       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   DOMAIN        7    169       FeoB-type G. {ECO:0000259|PROSITE:
FT                                PS51711}.
SQ   SEQUENCE   685 AA;  76175 MW;  4F05982EB04247E6 CRC64;
     MSSSNEIINV AFIGNPNCGK TSLFNDYTGA KLKVANWPGV TVEKKEGSYK FRDKEYKLVD
     LPGIYSLTSY TMEEKLSRQY ILEDEVDVII DVADASSLER NLYLTLQLIE LGKPVVLALN
     MMDIVEERGM EIDIHRLPEM LGIPVIPVSA RKKTGLEVLM HAVAHHKNKS SLEKLEHHHD
     ESSSTKHKHN HHYECVMVYS DDIEDMIDVV TERLQVKYPD MINFRWHAIK MLEMDDEITE
     RYPIGLADIV SRSYELDIIN QKYDFIEEVI QECLVNKDKK AHVTDIIDAI FTNRILGLPI
     FLAIMALVFF LTFTIGDSLK GVFEIFLKWF SGSTRGFLGS VGTNEVLISL VVDGIIAGVG
     GILTFLPNIF ILFLALAFLE DSGYMSRVAY VMDSIMGKLG LSGRAFIPMM LGFGCSVPAI
     MASRSLEDPK DRMKTILVTP FMSCSAKLPI YVIFSQMFFP KHALLVTYSM YLIGLMVAVM
     VALILNTFDK KKSLHSLLIE LPEYKAPNAR SIAIYVWGKV KDYLSKAGTT IFFASIIIWV
     ILNFGTHGMV TDMSQSFGAS IGKALSPIFA PTGLNQWKIV VALIAGIAAK EIVVSSMGIL
     YGIGNINSVA GMAGMSAGLA ATGFGALNAY SLMVFCLLYV PCAATIATIK RETHSWKWTI
     FAVCFQLGVA YFVSTLIYQV GKLFL
//
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