ID A0A1I0RP96_9RHOB Unreviewed; 354 AA.
AC A0A1I0RP96;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN ORFNames=SAMN04488515_3035 {ECO:0000313|EMBL:SEW43089.1};
OS Cognatiyoonia koreensis.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Cognatiyoonia.
OX NCBI_TaxID=364200 {ECO:0000313|EMBL:SEW43089.1, ECO:0000313|Proteomes:UP000199167};
RN [1] {ECO:0000313|EMBL:SEW43089.1, ECO:0000313|Proteomes:UP000199167}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17925 {ECO:0000313|EMBL:SEW43089.1,
RC ECO:0000313|Proteomes:UP000199167};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; FOIZ01000002; SEW43089.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I0RP96; -.
DR STRING; 364200.SAMN04488515_3035; -.
DR OrthoDB; 9783139at2; -.
DR Proteomes; UP000199167; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000199167};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00081}.
FT DOMAIN 115..336
FT /note="Heat-inducible transcription repressor HrcA C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01628"
SQ SEQUENCE 354 AA; 38721 MW; 34D5064309553A26 CRC64;
MSDTKQKLED LNDRSREVFR RVVEGYLETG DPVGSRTLTR TLSEQVSAAT VRNVMQDLEY
LGLLDSPHVS AGRIPTQLGL RMFVDGLLEV GDLSGEDRDR IDQTLGNNEQ DVATLLDRVG
SALSGVTKGA SLVLTPKHEA AIKHIEFVSL SAERALVVLV FADGHVENRL FSPPAGQTPS
SMREAANFLN AIAEGHTLSD LGAIIAREIA ARRQEIDKLA ADLVESGFAL WENEGESNER
LIVRGRGNLL SEHGTEADFD RIKTLFDDLE RKRDIAHFLD LAEDGDGVRI FIGSENKLFS
LSGSSLVVSP YMNADRKIIG AVGVIGPTRL NYGRIVPIVN YTAQRVGRMI ADRS
//
