ID A0A1I0RVR9_9RHOB Unreviewed; 1782 AA.
AC A0A1I0RVR9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Apple domain-containing protein {ECO:0000259|PROSITE:PS50948};
GN ORFNames=SAMN04488515_3330 {ECO:0000313|EMBL:SEW45427.1};
OS Cognatiyoonia koreensis.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Cognatiyoonia.
OX NCBI_TaxID=364200 {ECO:0000313|EMBL:SEW45427.1, ECO:0000313|Proteomes:UP000199167};
RN [1] {ECO:0000313|EMBL:SEW45427.1, ECO:0000313|Proteomes:UP000199167}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17925 {ECO:0000313|EMBL:SEW45427.1,
RC ECO:0000313|Proteomes:UP000199167};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
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DR EMBL; FOIZ01000002; SEW45427.1; -; Genomic_DNA.
DR STRING; 364200.SAMN04488515_3330; -.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000199167; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR CDD; cd01100; APPLE_Factor_XI_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR InterPro; IPR026284; A2-macglob_dom_prot_bac.
DR InterPro; IPR049120; A2M_bMG2.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR000177; Apple.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF21142; A2M_bMG2; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF00024; PAN_1; 1.
DR Pfam; PF07678; TED_complement; 1.
DR PIRSF; PIRSF038980; A2M_bac; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM00223; APPLE; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS50948; PAN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000199167};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1782
FT /note="Apple domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011440779"
FT DOMAIN 26..93
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
SQ SEQUENCE 1782 AA; 192302 MW; 5C2C2DFDC7852730 CRC64;
MAFRTIGLLA LGLSFLAGAV SADGPVPEKR TLYERNLDFV GSDISSIFDT TLQACEAACL
NDASCQAFTF NTRSNSCFPK SSVTDVSVYE GAVSGRIYKT DLAVLANLDA RVSELAFLQP
GDFERAQAQV ARVTSGFRDV PLAVRQAQIV LAETDASADW ASFSRLARNP NNRISGQALA
ASVNAYLRAL TDDDRRQALI EIAYNLERSD RGRTMIPALR AAQEIRFERN TEVDLEDAIG
KYGFRVSNTQ VDADSASPRI CAEFNEELIQ AGFDYTPFVQ LPDPAMVVSV SDGQLCLEGV
EHGNRYRIVL REGLPSVNGE TLSRQTELTL YVRDRSAAVR FPSRAYVLPR VGDIAIPVET
VNLSEIDVSL RRIDDRNIIR TMQDGYLNRP LYEYSQDRIS NEIGADVWEG TAQVVQDLNR
DVTTRIPMAD VLRGEPAGLY VLSAEIPGAD PYDNPPATQW FVLSDLGVAT YLGTDGLTAV
VRGLGDGQAK QGVEVELLSR ANAVLGTAMT NAEGVAYFEA GLTRGLGGNA PALVNVRQGE
DFAFLSLTDP AFDLSDRGVE GREPSPPIDV FLATDRGAYR AGETIHVTAL MRDPTTQAVP
GVPLTAILTR PDGVEYARTT STADMSGGHV FAMPVAGTAP RGTWRIAVLA DVEGETLAST
EVLVEDFLPE RIDFEMTLPE DIRVGDTPDL RIDAKYLFGP PAGDLGIEGE VLLRAAPSLE
GFEGYEFGRY DVPVDGSVRY LDGGTTAADG SAILSVNMPE TTAAQPLEMR VTARVTEGSG
RPIERQETVP VMPNQTMIGI KPLFDGTLPE NDEARFHVLA LTPDLELVPL EIQWTVNKVR
TRYQWYSYGG DWNWEPTTER TQVATGRATL GDAPLEIGAV VDWGRHEIMI ETLDADYRVA
ATDFYAGWYA PASAGDTPDV LQASLDAESY AIGDTARFRI VPRYAGTAVV SVMGDGLISM
QTAEVVEGEN IIDLTVTEEW GAGAYVTASV IRPMDVDAGR NPARALGLGY AQVDPGNKAL
DVSVLAPDIM EPRGDMNVSL IVDGITEGES AYVTLAAVDL GILNITGFNS PDPKDHYFGQ
RKLGVEMRDV YGRLIDGLNG TLGTVRSGGD AQAQMGTQSP PPTEELVTFF QGPVEVGADG
RVDLSFEMPA FNGTIRLMAV AWSQTGVGNA EHDVIVRDPV VVTASVPRFM APGDQSRMLI
EIVHTDGPAG EMGLNVSASG LGLASQLPAT FTLAPEGKQV FDVAFAAFDP GVHEISVSVT
TPDGRVLDKT LIVPVVFNDP EVSQISRFSL DPGQTFTFDD NAFAGMQAGT GSATLAVGPL
ARLDAPGLLN ALDRYPYGCT EQITSRAMPL LYLDNVANMM GLSSRNNVDE RIGTAISEVL
SNQSANGAFG LWSPSSGDLW LDAYVTDFLS RARQNGHAVP DIAFRNAVDN LRNAVNYYPD
FDRGGGDLAY ALMVLARESA ANTGDLRYYA DQKSESFSTP VALAQLGAAL AFYGDQPRAD
ALFNRAANRI VERYNTVERA TWRIDYGSNR RDTAAVLTLA VEAGSNAVDR EQMVTRLRSH
GNRVSTQEAT WTLLAVNALT RDASASGIMV DGQAPDGPIV RARDAGDGTQ PVLIRNDGAS
ATEVTVTTFG VPDVPEPAGG NGYRIERVYY NLDGEQIDLN DIGVGDRMVT VLTVIPFGEQ
EARLMINDPL PAGFEIDNPN LLQGGDVGGL DWLESARHEN AEFRSDRFLA AVDWRSDDSF
QLGYIVRAIS PGTFHHPAAS VEDMYRPEMR ANTDPGRVII NE
//
