ID A0A1I0SAX6_9BACT Unreviewed; 477 AA.
AC A0A1I0SAX6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Aromatic amino acid transport protein AroP {ECO:0000256|ARBA:ARBA00040443};
DE AltName: Full=Aromatic amino acid:H(+) symporter AroP {ECO:0000256|ARBA:ARBA00041728};
DE AltName: Full=General aromatic amino acid permease {ECO:0000256|ARBA:ARBA00042267};
GN ORFNames=SAMN04488122_5682 {ECO:0000313|EMBL:SEW53786.1};
OS Chitinophaga arvensicola.
OC Bacteria; Bacteroidota; Chitinophagia; Chitinophagales; Chitinophagaceae;
OC Chitinophaga.
OX NCBI_TaxID=29529 {ECO:0000313|EMBL:SEW53786.1, ECO:0000313|Proteomes:UP000199310};
RN [1] {ECO:0000313|EMBL:SEW53786.1, ECO:0000313|Proteomes:UP000199310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 3695 {ECO:0000313|EMBL:SEW53786.1,
RC ECO:0000313|Proteomes:UP000199310};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Permease that is involved in the active transport across the
CC cytoplasmic membrane of all three aromatic amino acids, phenylalanine,
CC tyrosine and tryptophan. {ECO:0000256|ARBA:ARBA00037317}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + L-phenylalanine(in) = H(+)(out) + L-
CC phenylalanine(out); Xref=Rhea:RHEA:28923, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00035783};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28925;
CC Evidence={ECO:0000256|ARBA:ARBA00035783};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + L-tryptophan(in) = H(+)(out) + L-tryptophan(out);
CC Xref=Rhea:RHEA:28879, ChEBI:CHEBI:15378, ChEBI:CHEBI:57912;
CC Evidence={ECO:0000256|ARBA:ARBA00036067};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28881;
CC Evidence={ECO:0000256|ARBA:ARBA00036067};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + L-tyrosine(in) = H(+)(out) + L-tyrosine(out);
CC Xref=Rhea:RHEA:28875, ChEBI:CHEBI:15378, ChEBI:CHEBI:58315;
CC Evidence={ECO:0000256|ARBA:ARBA00036013};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28877;
CC Evidence={ECO:0000256|ARBA:ARBA00036013};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FOJG01000002; SEW53786.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I0SAX6; -.
DR STRING; 29529.SAMN04488122_5682; -.
DR OrthoDB; 9780162at2; -.
DR Proteomes; UP000199310; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006865; P:amino acid transport; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR004840; Amoino_acid_permease_CS.
DR PANTHER; PTHR43495:SF4; AROMATIC AMINO ACID TRANSPORT PROTEIN AROP; 1.
DR PANTHER; PTHR43495; GABA PERMEASE; 1.
DR Pfam; PF00324; AA_permease; 1.
DR PIRSF; PIRSF006060; AA_transporter; 1.
DR PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE 4: Predicted;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 21..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..470
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
SQ SEQUENCE 477 AA; 52425 MW; 41B7185FDAA9E3F3 CRC64;
MKATNENTGA DHLKRGLQNR HIQLIALGGA IGTGLFLGIG PAAVLAGPSV ILGYALAGVI
AFFIMRQLGE MVVEEPVSGS FSHFAYKYWG TFAGFASGWN YWILYILVSM SELTAIGVYV
HFWWPEIPLW SSSLFFFIAI NALNLSSVKV YGEAEFWFSI IKVVAIIAMI CFGTYLLISG
SGGEQASIQN LWNDGGFFPK GLLESDGKGG FQGLFAAIAL IMFSFGGLEL IGITAAEADK
PEKTIPKATN QVIYRILIFY VGALIILFAL SPWRSITTTS SPFVMVFESL KGFQFTLMGH
TVYFTSLIAN VLNLIVLTAA LSVYNSCVYS NSRMLYGLAR QGNAPAFLSK LNHNHVPVKA
ILVSGLFAAI CIVINKVIPE KALEVLMSLV VSTLIINWLM ISVVHLKFKQ HKTAANIRTK
FPSFIYPVSN YICLVFLVGI LVLMWITGMK LPVALIPGWV IFLYLCYLLV KRNNRQG
//
