ID A0A1I0TII8_9SPHI Unreviewed; 612 AA.
AC A0A1I0TII8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=SAMN04488511_109179 {ECO:0000313|EMBL:SFA50796.1};
OS Pedobacter suwonensis.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Pedobacter.
OX NCBI_TaxID=332999 {ECO:0000313|EMBL:SFA50796.1, ECO:0000313|Proteomes:UP000198836};
RN [1] {ECO:0000313|Proteomes:UP000198836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18130 {ECO:0000313|Proteomes:UP000198836};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; FOJM01000009; SFA50796.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I0TII8; -.
DR STRING; 332999.SAMN04488511_109179; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000198836; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}.
FT DOMAIN 209..327
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 426..569
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 612 AA; 68502 MW; CE4689AC204E0AA5 CRC64;
MTDIIHLLPD AVANQIAAGE VVQRPASAVK ELLENSIDAG ADKIQLVIKD AGKALIQIID
NGCGMSVTDA RMCFERHATS KVKKAEDLFA IRTMGFRGEA MASIAAIAQV EMKTRRHEDE
IGTCISIEGA QVTNQEPVAT SPGTQISIKN LFFNTPARRN FLKSNPVEMR HIIDEFQRVA
LAHPGVFLSL HHDGVEIFNL PKGNLKQRIV HLFGNNYNER LVPVEEETTI INLKGYIGKP
AFAKKTRGEQ FFFVNNRFIK DPYLNHAVSS AFEELLPDDS YPLYVLFIEI DPSKIDVNVH
PTKTEIKYLD EKSIYAIMRS AVKRSIGRYN IAPTLDFDQE TGFSNMITHK AVEDIVPPSI
NFNPDFNPFA NDSSSTSGYA SSPRNYDAKP SAKNWGSLYD ITEQPVVEQT SIYEDETVLE
TKQKQYMQLH NRYIVSQIKS GLMVIDQQMA HERILYERFL VHLDDRKGAS QQSLFPQTIT
LNANDFELAK SLLDDIKSLG FDVREFGKNT LVVEGVPVDL GSSNINETQL FEQLIEGFKN
SQQELKLSKR DSLARSLAKN SAIKAGTSLG QEEMNTLIDE LFACKTPNFS VSGKPIIQTI
TLAELDKKFE KG
//
