ID A0A1I0V2V7_9CLOT Unreviewed; 889 AA.
AC A0A1I0V2V7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN04488528_100171 {ECO:0000313|EMBL:SFA69886.1};
OS Clostridium frigidicarnis.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=84698 {ECO:0000313|EMBL:SFA69886.1, ECO:0000313|Proteomes:UP000198619};
RN [1] {ECO:0000313|EMBL:SFA69886.1, ECO:0000313|Proteomes:UP000198619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12271 {ECO:0000313|EMBL:SFA69886.1,
RC ECO:0000313|Proteomes:UP000198619};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FOKI01000001; SFA69886.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I0V2V7; -.
DR STRING; 84698.SAMN04488528_100171; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000198619; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000198619}.
FT DOMAIN 685..701
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 611..618
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 889 AA; 100639 MW; B35CDF6E86431F82 CRC64;
MNLTPMMQQY LEIKGRYKDC ILFFRLGDFY EMFFEDAETA SKELELVLTG RDCGLEKRAP
MCGIPFHAST SYIGRLVNKG YKVAICEQVE DPALAKGIVK RDVIRVITPG TFTDESFIDE
CKNNFIMSLY ISEDKFISVS FADISTGEFY STSFRNSLEL IYDEISKFKP SEILLNSNIN
NDVKERLKDF GMSTTERHEN YFNSTENLQL LKDTFKCFDD CYDTPSNKGL ITYILETQKL
ALSNINSVEF YNITDTMTID INSRRNLELT ENIRDKGKKG SLLHVLDKTS TAMGSRTLRR
WIEMPLINKD LIDERLDSIE EVLNNIGLME DIGDSLKDVY DIERILGKIA AKSVNAKELM
SLKNSIGNIP KVKSLLENFS SPLLNNMFKN LDELQDIYSL IDTSVQDTPS LSVKEGNIIK
NGYNEAVDEL RNAKTHGKEW IASLEAEERE FTGIKSLKVG YNKVFGYYIE ISRANYNSIP
EGRYIRKQTL ANAERFITED LKTVEEKILG AEEKLISLEY KLFVEIRDNI EKEIGRMKSS
AKILAELDCL LSFARVSLDN NYVKPIVNLN DNINIKDGRH AVVEKVIPQG TFVSNDTLLN
RDDNQLLIIT GPNMAGKSTY MRQVALITLM AQIGCFVPAS YAEISLCDKI FTRIGASDDL
SGGKSTFMVE MWEVANILNN ATSKSLVLLD EVGRGTSTYD GLSIAWAVIE YICSKKDLKC
KTLFATHYHE LTDLENTLEG VKNYSVSVKE IDGSILFLRK IVEGGADKSY GIEVAKLAGL
PKEVVIRANS ILKDLEEKHE NNKVNVSSIK ENDEILEYKP TLEKAVETKE STVINEIAVD
FKESTQISFM DVAEDNFLDE IKEIDILNMT PMDAMNKLFD LVKKAKNLK
//