ID A0A1I0V6F9_9CELL Unreviewed; 280 AA.
AC A0A1I0V6F9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=2,5-diketo-D-gluconate reductase A {ECO:0000313|EMBL:SFA71126.1};
GN ORFNames=SAMN05421867_101150 {ECO:0000313|EMBL:SFA71126.1};
OS Cellulomonas marina.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Cellulomonadaceae;
OC Cellulomonas.
OX NCBI_TaxID=988821 {ECO:0000313|EMBL:SFA71126.1, ECO:0000313|Proteomes:UP000199012};
RN [1] {ECO:0000313|EMBL:SFA71126.1, ECO:0000313|Proteomes:UP000199012}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.6945 {ECO:0000313|EMBL:SFA71126.1,
RC ECO:0000313|Proteomes:UP000199012};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FOKA01000001; SFA71126.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I0V6F9; -.
DR STRING; 988821.SAMN05421867_101150; -.
DR OrthoDB; 9804790at2; -.
DR Proteomes; UP000199012; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO_KET_RED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000199012}.
FT DOMAIN 28..265
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 55
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 113
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 80
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 280 AA; 31046 MW; 7A255F6450EE96DD CRC64;
MGDQPGNVPT ILLNNGVEIP QLGFGVFQVD PAKTRDAVLT AFEVGYRHVD TAQMYRNEAG
VGEAVRDSGL PRDEVFITSK LNNGAHDPED ALKAFDGTLE TLGLEQVDLF LVHWPLPGIG
DFVETWKAME EIYASGRARA IGVSNFQVHH LNRLFDGTTV RPAVNQIEVH PYLTNESVRA
FGAEHQIATE AWSPIAQGTV LDDPVVERIA RETGRTPAQV VLRWHVQRGD IVFPKSVTRS
RVEENFALFD FELDETWMGA LSALNRDERT GPDPDTFNPS
//