ID   A0A1I0VDX4_9BACL        Unreviewed;      1236 AA.
AC   A0A1I0VDX4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Amino acid adenylation domain-containing protein/thioester reductase domain-containing protein {ECO:0000313|EMBL:SFA74237.1};
GN   ORFNames=SAMN05216312_101235 {ECO:0000313|EMBL:SFA74237.1};
OS   Cohnella sp. OV330.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Cohnella.
OX   NCBI_TaxID=1855288 {ECO:0000313|EMBL:SFA74237.1, ECO:0000313|Proteomes:UP000198686};
RN   [1] {ECO:0000313|EMBL:SFA74237.1, ECO:0000313|Proteomes:UP000198686}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OV330 {ECO:0000313|EMBL:SFA74237.1,
RC   ECO:0000313|Proteomes:UP000198686};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   EMBL; FOKE01000001; SFA74237.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I0VDX4; -.
DR   Proteomes; UP000198686; Unassembled WGS sequence.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 1.
DR   CDD; cd05235; SDR_e1; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.980; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR013120; Far_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR010080; Thioester_reductase-like_dom.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR   NCBIfam; TIGR01746; Thioester-redct; 1.
DR   PANTHER; PTHR44845:SF6; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR   PANTHER; PTHR44845; CARRIER DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   Pfam; PF07993; NAD_binding_4; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   PIRSF; PIRSF001617; Alpha-AR; 5.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   3: Inferred from homology;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198686}.
FT   DOMAIN          743..817
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   1236 AA;  135161 MW;  2669FD3181E27D4C CRC64;
     MSFNRTAAEP NPVRGSQQPV LLLPTDYPRH RRTYAYDTIE YALSQSLTRT LRESKREGNH
     DIAMLAAVYF AWICRLSGER EMAAGIAAAA GDAPVFVDAA AARTFGDLRD AVHRGLIAPE
     PPFDGVCETR FSVGFPLRAE HEQLNWQLRE RDGGWVVIVE YDASLFREAT IGRYVRYYAA
     LLEAALADPS ASFAGVDLLT EEDAAVYAAL NATAAAYDKH ATIHAMIERA AARYPDKTAV
     SSAEGKWTYR QLNEEANRTA RMLLDRGLCK GEFVTILMER SAELIVSLLG ILKAGGVYVP
     IDPEHPDERN RYIVEDTGSA FVLTKGKYVQ AAERLCAGIG SVKAIVDVEA GFPAYEGADN
     PDGGAGPDDL AYVIYTSGST GRPKGALIAH EGVVNLGESV RKDCGIGPDD VLTQFATYSF
     DASVWDTIGA LFYGAELYLL SPAERMSVEE FASAVERTGT TIVAILPTVF FNQLSAYLSD
     EGYRKLSRVH LITVAGEALY GEQVRAFQRK FKDAIAIVNV YGPTECTVCT TTHTIRDYVP
     DDLANVPIGR PIGNYKVYIV NEENRLCPVN VHGEVLISTV GLAKGYLNQP EKTKDAFVPN
     PFEPGSLIYK SGDFAKLLPD GTIEYVGRRD SQIKIRGHRI EIGEIEDAFA KIPNVQNIAV
     VPKKEKDGQN MLVGFFTSKD GARVAVAEVK RLLSEKLPSY FVPKLIVQLA DMPISPTGKI
     DRKKLAGYEL QDEQDRDDES YAPPANETQA AIAAAWQESL DLGRIGIHDD FFEIGGDSLA
     IIHVLVLLKP RFPDIGINDF FECRTIEKLA ERAERLSAGA DASRKAYVGG EVIPLDEHPA
     VLGQASAERL HDRPSAVLLT GATGYLGAYL LYELLVQSEA KIICLARPSG SDSAQFRIQK
     TLVHYFGASS LDLLDGRVYV VEGDLSQPGL GLSPADAHFV GANADAILHS AADVRHFGDA
     DQFDKSNVLA TRHLIELAEG SERSVRFHHI STLGIPEDLA LSGQWEEQLS RAAFDPDLKV
     DNLYTQSKLE AEKLLMAAAN RGLAVNIYRA GNLSCHAESG KFQQNIDNNA FYRMIKAMLL
     LGKAPKANWD VDFTPIDYAG KSIVHLALRP DTAGRLFHIC NPEPVRYERM IEMLGALGYP
     VETLDFADYS NWLFDSAVPK DPEAVKLAIA QLEGDGAKDS DYRYGCPAAS SFLEATDIRC
     APADESYLRQ MIEHAVSIGY FPAPKALVQA VGRGGR
//