ID   A0A1I0WZ91_9ACTN        Unreviewed;      1189 AA.
AC   A0A1I0WZ91;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=SAMN05192575_10231 {ECO:0000313|EMBL:SFA94049.1};
OS   Nocardioides alpinus.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Nocardioides.
OX   NCBI_TaxID=748909 {ECO:0000313|EMBL:SFA94049.1, ECO:0000313|Proteomes:UP000199113};
RN   [1] {ECO:0000313|EMBL:SFA94049.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.10697 {ECO:0000313|EMBL:SFA94049.1};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; FOKC01000002; SFA94049.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I0WZ91; -.
DR   STRING; 748909.SAMN05192575_10231; -.
DR   OrthoDB; 9803237at2; -.
DR   Proteomes; UP000199113; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; PHP domain-like; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          14..81
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
SQ   SEQUENCE   1189 AA;  131177 MW;  1B204D48C64546BC CRC64;
     MSAGSSTSSV DNFVHLHVHT EYSMLDGASL LDGLFTRTSD LGMPAIAMTD HGNLHGAYDF
     YRKAKQHGVK PIIGIEAYIT PGTMRGERRR VRWGQGDLAE EGGNDVAGGG AYTHMTMWAE
     STEGMHNLFR LSTRSSLEGY YFKPRMDKEI LAEHSKGLIV STGCPSGAIQ TRLRLGQYDE
     AVREAGELQE IFGKDNVFLE LMDHGISIEK RVRDDLLRLG KEMNLPPIAT NDSHYNNPED
     AAAHDALICV ASGKRLSDTN RLKFDGGGYY IKSPAEMRAL WADEFGMPEA CDNTLAIAER
     CDVEFTESTG GYMARADVPA GETEDSWFRK EVWRGIEARY PGDRLDQSVR DRVEMELAII
     SQKGYCGYYL VVADFINWAK DNGIRVGPGR GSGAGSIAAY SLRITDLCPL EHGLFFERFL
     NPERPSMPDF DIDFDDARRG EVITYVSDKY GADRVAQIAT FGRLKAKAAI KDAARVLDHG
     FAISDRITKA LPADVMGKGV PLKEIFNPEH KRYRDGGEFR TLYDQDADVR TIYETAVGLE
     GQIRNWGVHA AGVIMSSEPL VDIVPIMARP QDGAVITQFD YPMCESLGLV KMDFLGLSNL
     RTLEDALINI GVNRDEQVVL EELPFDDRAT YELMGRGDTL GVFQLDGSGM RALLRSMQPD
     QFADITAVSA LYRPGPMGAD SHNKYARRKN GREPIDPIHP ALAEALEPVL GETYGLIVYQ
     EQVMAIAQVL AGFTLGAADN LRRAMGKKKK EELDKQYAGF QAGMLERSFP QVAIDKLWEI
     LLPFSDYAFN KSHSAAYGVI TYWTAYLKAN YPTEYMAALL TSVKDDKDKM AIYLNECRRM
     KIQVLPPDVN ESHANFTPVG NDIRFGLTAV RNVGSNVVDG IVSGREQKGR YADFNDFMEK
     VPALVCNKRV VESLIKAGAF DDMKHKRRAL VAVHETAVDQ FVDLKKNEAI GQDSLFGGLG
     DDDAGFGVTV TIPDIDDWDK LTLLGHEREM LGLYVSDHPL LGLEHVLSQG TDCTIGQLML
     DEERPHGSTI TVSGLVTSVA RKITKRGDPW ATITLEDLDG AIEVLLFPSA YTLASTLLVE
     DQVVRIKGQL SRDKDQPELR AQEVTAPDLT QGPAGPVVIS LPSTRCTPPV VAQLRDVLGT
     HPGMTEVQLR LLTRSSTKLL RLDDNLRVSP SPALFADLKQ LLGPGCLTG
//