ID A0A1I0X4U8_9BACL Unreviewed; 674 AA.
AC A0A1I0X4U8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:SFA95687.1};
GN ORFNames=SAMN05216312_102495 {ECO:0000313|EMBL:SFA95687.1};
OS Cohnella sp. OV330.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Cohnella.
OX NCBI_TaxID=1855288 {ECO:0000313|EMBL:SFA95687.1, ECO:0000313|Proteomes:UP000198686};
RN [1] {ECO:0000313|EMBL:SFA95687.1, ECO:0000313|Proteomes:UP000198686}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OV330 {ECO:0000313|EMBL:SFA95687.1,
RC ECO:0000313|Proteomes:UP000198686};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; FOKE01000002; SFA95687.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I0X4U8; -.
DR Proteomes; UP000198686; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198686};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 67..258
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 311..649
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 674 AA; 74692 MW; 21BB8F003715EEB8 CRC64;
MSDKLTEEAE RRGIRNRRHF SIRLNFFFFT VFGLFSVLII RLAYLQFVEG PNLKEQEHQL
ATKDVSIPPI RGNIYDSTGF PIAYSTSTQS LYFTLEPGTK KAEGLALAAR IEAVFKQYGD
QAKEPLTAAE IYEDMDFEGK VHYPFQQRRI KSGLTDQEIA YFSEHRDQFE GIDIVEESIR
QYSTERVATQ LVGYMKQLSG ATSLDFYKDI NKDQEDPTLK YLDTEDVGFD GLELMYQSEL
RGRNGLKTYP VNNQSQIIGP MELTKPVKGD NLYLTINKDV QLATQNAITQ HLQKIRTSNN
KQERAPNAKT GYAVAMEVKT GKVVAMASMP DYDANVWQGG ISAKNYEQFQ FYLSNGAIRE
VQAPYEDEKE RKKHPSSLVN LGSTQKPLTI LLGLNEGLIS TGSTMSDPGY FEFGREGHKT
KVRNAGSAAN GTLTPSSAIA HSSNAYMAKM VGNSLYMRDG SKGLDVWDKY MKEFGLGVKT
ESGLPGESKG SINYYIESKR GSAQSALIYS SFGQQGRYTA LQLAQYATTL ASRGTRLKPQ
FVDRIEDTDG NVVQGYESEV LNKIEFPKSY WQTIESGMSQ VKVQGFDDFK YSFRRKTGTS
EQDVGGGRVE NAVFIAYAPA NDPKLAVAVV VPEGGYGGWG AAPIARKIFD AYDAAVGLTD
AGPAKTTTGT AAGQ
//
