ID   A0A1I1BAJ4_9PSEU        Unreviewed;       264 AA.
AC   A0A1I1BAJ4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:SFB47415.1};
GN   ORFNames=SAMN05216266_1134 {ECO:0000313|EMBL:SFB47415.1};
OS   Amycolatopsis marina.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Amycolatopsis.
OX   NCBI_TaxID=490629 {ECO:0000313|EMBL:SFB47415.1, ECO:0000313|Proteomes:UP000243799};
RN   [1] {ECO:0000313|Proteomes:UP000243799}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.3568 {ECO:0000313|Proteomes:UP000243799};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HIBADH-related family.
CC       {ECO:0000256|ARBA:ARBA00009080}.
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DR   EMBL; FOKG01000013; SFB47415.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I1BAJ4; -.
DR   STRING; 490629.SAMN05216266_1134; -.
DR   Proteomes; UP000243799; Unassembled WGS sequence.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR048666; RedAm-like_C.
DR   PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR   PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   Pfam; PF21761; RedAm-like_C; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000243799}.
FT   DOMAIN          2..128
FT                   /note="6-phosphogluconate dehydrogenase NADP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03446"
FT   DOMAIN          135..259
FT                   /note="NADPH-dependent reductive aminase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21761"
SQ   SEQUENCE   264 AA;  28141 MW;  3211DBAC80D5AC3D CRC64;
     MTVWDEDTVL ADTLPARGVS RADSLRTAFA AASLILLCVE DYDAVQRVLE RAESHVGGVD
     VLNLTSGTSA EAEQVEAWLD ARGSHYLDAA LMAHPEHVGK PDTVLVYSGS GEVFERHETL
     LAHLGGATYL GKSVGTAALY DVAMLGLAWA TLIGFLQTAA LLGTAQVPAA TVAPLLTRWL
     STTVSDVIAD YARQVDEQHY PGDEEWLELD APLMDHLIEA GRTRGLDNAL PELIKSLTDR
     GIDAGHGRNS FASLVEVLRG APTG
//