ID A0A1I1CUK2_9PSEU Unreviewed; 720 AA.
AC A0A1I1CUK2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Putative drug exporter of the RND superfamily {ECO:0000313|EMBL:SFB64083.1};
GN ORFNames=SAMN05216266_1406 {ECO:0000313|EMBL:SFB64083.1};
OS Amycolatopsis marina.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis.
OX NCBI_TaxID=490629 {ECO:0000313|EMBL:SFB64083.1, ECO:0000313|Proteomes:UP000243799};
RN [1] {ECO:0000313|Proteomes:UP000243799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.3568 {ECO:0000313|Proteomes:UP000243799};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FOKG01000040; SFB64083.1; -; Genomic_DNA.
DR RefSeq; WP_043830838.1; NZ_FOKG01000040.1.
DR AlphaFoldDB; A0A1I1CUK2; -.
DR STRING; 490629.SAMN05216266_1406; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000243799; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000243799};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 556..577
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 597..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 673..695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 228..352
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 720 AA; 75133 MW; CE4E7B2293B7039B CRC64;
MTASTRTDSH PPDTAALSLQ RSGPLGRLGT RMAARAWWVV AAWVLVVGAL GSLAPTVFTS
LAGAGWQANG SESVQVRELA QQHFGGNASS AIQVVVQSDD APISDPAVQQ ILGQAADVLA
QDNRIGQLVP PKPGMTISPD GRTGILLAGA NANTDDMVRA VDDLKADLTG LSTSSVHVYP
TGASALWSDF NEANHDAMIQ AEMVSWPVTL AIMVLAFGSL VAAGLPLLLT LAGLGASAGA
LVLLNEITPI SVWAMNFAMM FALALGIDYA LFLVVRFRDA LRKLADARAA VAETMDTAGK
AVLLSGITVL VSLSAVLLVP APAVRTMAVG IMLAVVFVLA ATLTLLPAVL GKLGGRVNSL
ALPWAKRTEA HSPRFSRWGQ LLSRKPWPFA LGALLVLIAL SLPVFGLKVA MPSIQVVPND
APVRQGYEAV QDSFGDGAPG MLQIITPAAD AQATAAQAED TDGIALVTPP QPASDGSDYA
LVQAMPTVDP SSPQLGDTLD RLRDTLPDGA LVGGAPAENL DLQTALNDYL PLVVGVILAL
GFVLLLVALQ APVIALLGTV VSLLSTGAAF GVAKLIFQDG HLAGLLGFTP QGFLDGWGPV
FFFAMIFAIA MDYTVFLLAS AKEHYELTGS PRRALIDGLA HSGRVIFAAA AVMVAVFFTF
ALADPLPPKE MGIILGVAVL LDAALIRLVL LPVLLRITGH SAWWSPRWLR KALPTITFSH
//
