ID A0A1I1D7G8_9FIRM Unreviewed; 258 AA.
AC A0A1I1D7G8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Uridine phosphorylase {ECO:0000256|ARBA:ARBA00021980, ECO:0000256|RuleBase:RU361131};
DE EC=2.4.2.3 {ECO:0000256|ARBA:ARBA00011888, ECO:0000256|RuleBase:RU361131};
GN ORFNames=SAMN02910398_00232 {ECO:0000313|EMBL:SFB68750.1};
OS Butyrivibrio sp. YAB3001.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Butyrivibrio.
OX NCBI_TaxID=1520812 {ECO:0000313|EMBL:SFB68750.1, ECO:0000313|Proteomes:UP000198944};
RN [1] {ECO:0000313|EMBL:SFB68750.1, ECO:0000313|Proteomes:UP000198944}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YAB3001 {ECO:0000313|EMBL:SFB68750.1,
RC ECO:0000313|Proteomes:UP000198944};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the reversible phosphorylytic cleavage of uridine
CC to uracil and ribose-1-phosphate. {ECO:0000256|RuleBase:RU361131}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=phosphate + uridine = alpha-D-ribose 1-phosphate + uracil;
CC Xref=Rhea:RHEA:24388, ChEBI:CHEBI:16704, ChEBI:CHEBI:17568,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.3;
CC Evidence={ECO:0000256|ARBA:ARBA00001020,
CC ECO:0000256|RuleBase:RU361131};
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway;
CC uracil from uridine (phosphorylase route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00004825, ECO:0000256|RuleBase:RU361131}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the PNP/UDP phosphorylase family.
CC {ECO:0000256|ARBA:ARBA00010456, ECO:0000256|RuleBase:RU361131}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FOKR01000002; SFB68750.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I1D7G8; -.
DR STRING; 1520812.SAMN02910398_00232; -.
DR OrthoDB; 9772602at2; -.
DR UniPathway; UPA00574; UER00633.
DR Proteomes; UP000198944; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004850; F:uridine phosphorylase activity; IEA:UniProtKB-EC.
DR GO; GO:0009164; P:nucleoside catabolic process; IEA:UniProt.
DR GO; GO:0009166; P:nucleotide catabolic process; IEA:InterPro.
DR GO; GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway.
DR CDD; cd17767; UP_EcUdp-like; 1.
DR Gene3D; 3.40.50.1580; Nucleoside phosphorylase domain; 1.
DR InterPro; IPR018016; Nucleoside_phosphorylase_CS.
DR InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR InterPro; IPR010058; Uridine_phosphorylase.
DR NCBIfam; TIGR01718; Uridine-psphlse; 1.
DR PANTHER; PTHR43691:SF11; FI09636P-RELATED; 1.
DR PANTHER; PTHR43691; URIDINE PHOSPHORYLASE; 1.
DR Pfam; PF01048; PNP_UDP_1; 1.
DR SUPFAM; SSF53167; Purine and uridine phosphorylases; 1.
DR PROSITE; PS01232; PNP_UDP_1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU361131};
KW Reference proteome {ECO:0000313|Proteomes:UP000198944};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361131}.
FT DOMAIN 23..228
FT /note="Nucleoside phosphorylase"
FT /evidence="ECO:0000259|Pfam:PF01048"
SQ SEQUENCE 258 AA; 28009 MW; AA2C29448B876DD2 CRC64;
MVDYTEGAGY QYHTHVKKGD VGRYVILTGD PGRCETISHL FDNPEFIAYN REYNTYTGTI
NGEKVSVMST GIGGASTAIA VEELVKCGAD TFIRMGTSGG MQDDVIGGDI VIANGAIRAE
GTSKEYAPIE YPAVASFDVV NSLVQAAKKT NAKYHVGVVQ CKDSFFGQHE PETKPVGPEL
LYKWDAWIKC GALCSEMESS TLFIVGDYLR VRTGAVLLVV ANQERAKKGL SNPQAHDMDI
VYKTTIEAIK SLIDMDKA
//
