ID A0A1I1FA08_9BACT Unreviewed; 612 AA.
AC A0A1I1FA08;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN05421780_10298 {ECO:0000313|EMBL:SFB95792.1};
OS Flexibacter flexilis DSM 6793.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Flexibacteraceae;
OC Flexibacter.
OX NCBI_TaxID=927664 {ECO:0000313|EMBL:SFB95792.1, ECO:0000313|Proteomes:UP000199514};
RN [1] {ECO:0000313|EMBL:SFB95792.1, ECO:0000313|Proteomes:UP000199514}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6793 {ECO:0000313|EMBL:SFB95792.1,
RC ECO:0000313|Proteomes:UP000199514};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; FOLE01000002; SFB95792.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I1FA08; -.
DR STRING; 927664.SAMN05421780_10298; -.
DR OrthoDB; 890870at2; -.
DR Proteomes; UP000199514; Unassembled WGS sequence.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 3.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR43304:SF1; PAC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43304; PHYTOCHROME-LIKE PROTEIN CPH1; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF08448; PAS_4; 2.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00086; PAC; 2.
DR SMART; SM00091; PAS; 3.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 3.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 2.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000199514}.
FT DOMAIN 148..201
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 204..256
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 257..301
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 333..385
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 403..612
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 612 AA; 70299 MW; BD7B8D0CA58C6F34 CRC64;
MNSIQLEIDL YKTFAENIPN SAVLMFDKDM RFFFAAGEEL RRNHYNPEFM VGKTLQEVVP
EKSYQALKLC YERVLNGERI QSETNTGTLV YINTFIPIQS RATGQYYGVA ISQNVTDLQT
TKQQLAESES QYKLAIQGFG AGIWDLFDVN QKQQWWSPKF YELLGYEYEE IEPTTDTFYE
LLRPDYVDKV QEGVQRHMET DVPFSMEYPL RTKSGVYKWF EAHGQVSRGE NGIPKRFVGS
VIDIDARKRA EQLLIEKEQL FSAVFQQTFQ FVSLLEPSGK IIESNETALR LRGLTLEQVK
GLYFWDTPWW NASAQSQQQL QEAIQKAAAG EFVRYETEIL ASNNQVFIID FSVKPLRDSE
GKTLMLITEG RDITALKKSQ REAVETSQIL LLQNKQLEDF AHITSHNLRA PIGNMIMIAD
WLTKTHDDNE KDFLIQNLCN TASKALDTID ILAQILRVRK DLKKEQDVLS FAQILQSVKN
TLSAWIREAD VTITENFEQA PTILYPALYL DSVFQNLLSN SIKYKSPDRP CQVQVRTFQE
NGHIVLIFED NGLGIDLTHN RERVFGLYKT FHNNTDARGV GLFLVKNQIE ALGGHIEIES
QPNVGTTFKI TF
//
