ID A0A1I1FKY5_9LACT Unreviewed; 399 AA.
AC A0A1I1FKY5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Mannonate dehydratase {ECO:0000313|EMBL:SFC00067.1};
GN ORFNames=SAMN04488102_102155 {ECO:0000313|EMBL:SFC00067.1};
OS Alkalibacterium subtropicum.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC Alkalibacterium.
OX NCBI_TaxID=753702 {ECO:0000313|EMBL:SFC00067.1, ECO:0000313|Proteomes:UP000199612};
RN [1] {ECO:0000313|EMBL:SFC00067.1, ECO:0000313|Proteomes:UP000199612}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23664 {ECO:0000313|EMBL:SFC00067.1,
RC ECO:0000313|Proteomes:UP000199612};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has no detectable activity with D-mannonate and with a panel
CC of 70 other acid sugars (in vitro), in spite of the conservation of the
CC residues that are expected to be important for catalytic activity and
CC cofactor binding. May have evolved a divergent function.
CC {ECO:0000256|ARBA:ARBA00003553}.
CC -!- SIMILARITY: Belongs to the mandelate racemase/muconate lactonizing
CC enzyme family. GalD subfamily. {ECO:0000256|ARBA:ARBA00010339}.
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DR EMBL; FOLT01000002; SFC00067.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I1FKY5; -.
DR STRING; 753702.SAMN04488102_102155; -.
DR OrthoDB; 9775391at2; -.
DR Proteomes; UP000199612; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR GO; GO:0009063; P:amino acid catabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR InterPro; IPR034589; D-mannonate_dehydratase-like.
DR InterPro; IPR034593; DgoD-like.
DR InterPro; IPR036849; Enolase-like_C_sf.
DR InterPro; IPR029017; Enolase-like_N.
DR InterPro; IPR029065; Enolase_C-like.
DR InterPro; IPR018110; Mandel_Rmase/mucon_lact_enz_CS.
DR InterPro; IPR013342; Mandelate_racemase_C.
DR InterPro; IPR013341; Mandelate_racemase_N_dom.
DR PANTHER; PTHR48080; D-GALACTONATE DEHYDRATASE-RELATED; 1.
DR PANTHER; PTHR48080:SF6; STARVATION-SENSING PROTEIN RSPA; 1.
DR Pfam; PF13378; MR_MLE_C; 1.
DR Pfam; PF02746; MR_MLE_N; 1.
DR SFLD; SFLDS00001; Enolase; 1.
DR SFLD; SFLDG00033; mannonate_dehydratase; 1.
DR SMART; SM00922; MR_MLE; 1.
DR SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
DR PROSITE; PS00908; MR_MLE_1; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 132..252
FT /note="Mandelate racemase/muconate lactonizing enzyme C-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM00922"
SQ SEQUENCE 399 AA; 45118 MW; AE0419A63C8ACB06 CRC64;
MKPTIITNIK SYGIKPDRHN LVVVKVETDK GVSGLGCATF QFRPLAVQSL VDDYLKPLLV
GKDANNIEDL WHLMTVNAYW RNGPVINNAI SGVDMALWDI KGKLSDMPLY QLLGGKSRNK
VSAYAHAVGD TLDELFEQID THLANGFRYI RCQLGFYGGT DLNAETENEA LSGVYYDQQT
YMDRTLEMFE AIEAKYGHSF QMLHDVHERL HPNQAVQFAK KVEPFNVYFL EDILPPDQTE
WLKLVRTQTA TPIAIGELFN NPMEWKALIA SHQLDYLRVH VSQIGGITPA LKLAHLCDAF
GVRVAWHTPS DISPIGLAVN THLNMHLHNA AVQESLVLKD NTKQLFKHSP EPKQGHFYPI
ERPGIGVDFD KELARDYPVV YRSHDWTQSR LPDGTLFTP
//
