ID   A0A1I1FQ74_9GAMM        Unreviewed;       284 AA.
AC   A0A1I1FQ74;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=NAD-dependent protein deacetylase, SIR2 family {ECO:0000313|EMBL:SFC01607.1};
GN   ORFNames=SAMN05660443_1150 {ECO:0000313|EMBL:SFC01607.1};
OS   Marinospirillum celere.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC   Oceanospirillaceae; Marinospirillum.
OX   NCBI_TaxID=1122252 {ECO:0000313|EMBL:SFC01607.1, ECO:0000313|Proteomes:UP000199058};
RN   [1] {ECO:0000313|EMBL:SFC01607.1, ECO:0000313|Proteomes:UP000199058}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 18438 {ECO:0000313|EMBL:SFC01607.1,
RC   ECO:0000313|Proteomes:UP000199058};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FOLH01000002; SFC01607.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I1FQ74; -.
DR   STRING; 1122252.SAMN05660443_1150; -.
DR   OrthoDB; 9800582at2; -.
DR   Proteomes; UP000199058; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1600.10; SIR2/SIRT2 'Small Domain; 1.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR003000; Sirtuin.
DR   InterPro; IPR026591; Sirtuin_cat_small_dom_sf.
DR   InterPro; IPR026590; Ssirtuin_cat_dom.
DR   PANTHER; PTHR11085; NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED; 1.
DR   PANTHER; PTHR11085:SF2; NAD-DEPENDENT PROTEIN LIPOAMIDASE SIRTUIN-4, MITOCHONDRIAL; 1.
DR   Pfam; PF02146; SIR2; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   PROSITE; PS50305; SIRTUIN; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU00236}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199058};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00236}.
FT   DOMAIN          10..284
FT                   /note="Deacetylase sirtuin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50305"
FT   ACT_SITE        131
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         139
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         142
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         190
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         193
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
SQ   SEQUENCE   284 AA;  31818 MW;  21827BFE23D40B48 CRC64;
     MQLAKAYPAS FSVETTSNQL FHFFNEHHKW LVLTGAGIST GSGIPDYRDD EGQWKRRQPV
     QHQEFMTSPQ VRQRYWARAL AGFEAFRSAR PGAGHLALAA LEKQGRIQQV ITQNVDRLHQ
     KAGSKKVIDL HGRGDTVSCQ SCGFRTMRYA YHQHLIELNP QYDKKHASLA PDGDADLEQQ
     NFSDFQLLDC PRCSGIIKPD VVFFGDLIPP ATRHAAEQAM QAADGLLVVG SSLMVYSGYR
     FCRLAKQTNK PIIAINRGKT RADELLDLKV NQPAESILTR LADL
//