ID A0A1I1G7U8_9BURK Unreviewed; 304 AA.
AC A0A1I1G7U8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:SFC07615.1};
GN ORFNames=SAMN05216344_108124 {ECO:0000313|EMBL:SFC07615.1};
OS Polaromonas sp. OV174.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Polaromonas.
OX NCBI_TaxID=1855300 {ECO:0000313|EMBL:SFC07615.1, ECO:0000313|Proteomes:UP000218980};
RN [1] {ECO:0000313|EMBL:SFC07615.1, ECO:0000313|Proteomes:UP000218980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OV174 {ECO:0000313|EMBL:SFC07615.1,
RC ECO:0000313|Proteomes:UP000218980};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
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DR EMBL; FOKZ01000008; SFC07615.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I1G7U8; -.
DR STRING; 1855300.SAMN05216344_108124; -.
DR OrthoDB; 9777604at2; -.
DR Proteomes; UP000218980; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000218980}.
FT DOMAIN 16..178
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 183..302
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 189
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 304 AA; 31609 MW; E898DC301634DF1A CRC64;
MNSTHPKSYE ASAALKVAFL GLGVMGYPMA GHLALAGHQV TVYNRSAAKA AAWCSEFART
KSPHQAATPK LAAADADIVF CCVGNDDDLR SVTLGADGAF AGMKPGAIFV DHTTASATVA
RELYAAAKQI GLQFIDAPVS GGQAGAQNGA LTVMCGGDAA AFDAVKPAGM AFSKAFTLMG
EAGAGQLTKM VNQICIAGLV QGLSEAVAFG QKAGLNVNQV LEVIGKGAAQ SWQLDNRGKT
MAADQFDFGF AVDWMRKDLG LVLDEAKRNG ARLPVTALVD QFYADVQAMG GQRWDTSSLI
KRLK
//
