ID   A0A1I1GHL0_9BACT        Unreviewed;       396 AA.
AC   A0A1I1GHL0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Glutathione-independent formaldehyde dehydrogenase {ECO:0000313|EMBL:SFC10752.1};
GN   ORFNames=SAMN05216167_101468 {ECO:0000313|EMBL:SFC10752.1};
OS   Spirosoma endophyticum.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cytophagaceae; Spirosoma.
OX   NCBI_TaxID=662367 {ECO:0000313|EMBL:SFC10752.1, ECO:0000313|Proteomes:UP000198598};
RN   [1] {ECO:0000313|EMBL:SFC10752.1, ECO:0000313|Proteomes:UP000198598}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 26130 {ECO:0000313|EMBL:SFC10752.1,
RC   ECO:0000313|Proteomes:UP000198598};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; FOLQ01000001; SFC10752.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I1GHL0; -.
DR   STRING; 662367.SAMN05216167_101468; -.
DR   OrthoDB; 9787435at2; -.
DR   Proteomes; UP000198598; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08282; PFDH_like; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR014184; HCHO_DH_non_GSH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   NCBIfam; TIGR02819; fdhA_non_GSH; 1.
DR   PANTHER; PTHR42813:SF3; GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198598};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          34..143
FT                   /note="Alcohol dehydrogenase-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08240"
FT   DOMAIN          196..263
FT                   /note="Alcohol dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00107"
SQ   SEQUENCE   396 AA;  41557 MW;  9FDFC6367151A096 CRC64;
     MCHNHGVAYI SPGVVEVQSI DYPKLALGDR KCEHGVILQI VSTNICGSDQ HMVRGRTTAP
     AGLVLGHEIT GLVIEAGRDV EFIKEGDLVS VPFNIACGRC RNCKAGQTGI CLNVNPGRAG
     GAYGYVDMGG WIGGQAEYVM VPYADFNLLK FPDKDQAMAK IRDLTLLSDI FPTGYHGAVT
     AGVGPGSIVY VAGAGPVGLA CAASCHLLGA AVVMVGDMIP ERLEQAKSFG CEPIDLRSET
     PLADQIAQLV GVPEVDSVID CVGFEAKGHG AGADAEQPAT VLNAAMTITR AGGAIGIPGL
     YVTGDPGAKD KAAQEGSLSI RIGLGWAKSH SFFTGQTPVM KYHRQLMNTI LYDKIQIAKA
     VNVEVISLDK APKGYQDFDK GAAKKFVIDP HGLIPN
//