ID A0A1I1IF80_9ACTN Unreviewed; 1301 AA.
AC A0A1I1IF80;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=galactosylceramidase {ECO:0000256|ARBA:ARBA00012657};
DE EC=3.2.1.46 {ECO:0000256|ARBA:ARBA00012657};
DE AltName: Full=Galactosylceramidase {ECO:0000256|ARBA:ARBA00033098};
GN ORFNames=SAMN04487968_105271 {ECO:0000313|EMBL:SFC34914.1};
OS Nocardioides terrae.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=574651 {ECO:0000313|EMBL:SFC34914.1, ECO:0000313|Proteomes:UP000198832};
RN [1] {ECO:0000313|EMBL:SFC34914.1, ECO:0000313|Proteomes:UP000198832}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.7056 {ECO:0000313|EMBL:SFC34914.1,
RC ECO:0000313|Proteomes:UP000198832};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 59 family.
CC {ECO:0000256|ARBA:ARBA00005637}.
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DR EMBL; FOLB01000005; SFC34914.1; -; Genomic_DNA.
DR STRING; 574651.SAMN04487968_105271; -.
DR OrthoDB; 9802318at2; -.
DR Proteomes; UP000198832; Unassembled WGS sequence.
DR GO; GO:0004336; F:galactosylceramidase activity; IEA:InterPro.
DR GO; GO:0006683; P:galactosylceramide catabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR010496; 3-keto-disaccharide_hydrolase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR049161; GH59_cat.
DR InterPro; IPR001286; Glyco_hydro_59.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR15172; GALACTOCEREBROSIDASE; 1.
DR PANTHER; PTHR15172:SF1; GALACTOCEREBROSIDASE; 1.
DR Pfam; PF06439; 3keto-disac_hyd; 1.
DR Pfam; PF02057; Glyco_hydro_59; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 3: Inferred from homology;
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Reference proteome {ECO:0000313|Proteomes:UP000198832};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919}.
FT SIGNAL 1..41
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 42..1301
FT /note="galactosylceramidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011721488"
FT DOMAIN 73..419
FT /note="Glycosyl hydrolase family 59 catalytic"
FT /evidence="ECO:0000259|Pfam:PF02057"
FT DOMAIN 704..841
FT /note="3-keto-disaccharide hydrolase"
FT /evidence="ECO:0000259|Pfam:PF06439"
FT REGION 325..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..635
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1301 AA; 138358 MW; 645075A62F659FDF CRC64;
MQNEGRTRPH GSEGSSRTAL RFAIGTASLA VLAATATPAV AAAGSGAPED AVQITVKGTD
VAAAAQNRNG LTFKGFGVLT ANSTSSLLMD YKAEHPEKYW ELIETLFGGD HPIMDTVKIE
MGNDRNTSTG PNPGSMRTRD EYPNVQREPG FQLAADAQKV AKRPLQVSIL RWNTPTWVKS
NADQYIWFKN TVLAAYREYG IMVDSINPDT NETGNPNEDL YKQFSASLRN DAKGYEGATA
DDPNNGFASA TEANLFHSIR TVAADTVGTP PTNFGDQMTD PADSSLRDAV DVVGFHYSSA
DDSHGNLKKI AEVLDKEVWN SEGQATFSNT ADRPNNTNSD EQGGTGTEIG GTNSPLEMAN
WVTTGFASSR RSLYVFQPAI GSFYDGFQYS SKELVSARDP WSGWIYYDGG LAVLQQFTQF
ATLGWENPTG DADANGIWRA VPQASGSELG TGNPPSGARQ GGASYTTLAA PDASDFSTVI
VNDSKYTKTY RVTADGMDLG RDKTMEVWET RAADAGEAYD ANYVKPLQEI RPDADGTYTV
TVKPWSTVTA TTLDHATRGS HGSLTARDGY GNNLPTSREY TDRNGGRDVL DTDRTGRRNG
DTHDDVLYAD DFDYSREPDI KSYDPRRHRL VDSGESYLDS RGAKPKPAGT PDVQPEDDGA
TPRYTDDTNG AFESVATADR SHGRVLRQQI GTGMAGGAWN GGDPKTTIGD NRWANYRVSV
DVRFDDATGT YATVGAREQG GTANGQNVSA AELRLDPTGA WTFQRFGSVV ARGNAGDEPG
TRFAAGAGAW NRVAVQVAGD VYTAYINGVE VTSYTDPTPQ ATGRIQLGSG FTFTQFDNLE
VTTVPGYTPY YTDIIDGMHQ TSWADTSRPV LEFDDQWSHV NGQGMFEWQR TASRSTGQGA
TMSYTFRGTG LDIIGGNPGT TKLNVVVDGV QVATSAPTWS AGSERTTFTL RGLRNGRHTV
TFETANSASI NIDAVGVVKA NADSAEADTT ALRAAVERTA QLHEGDYNPA TWKPLADIRA
DAEWALRHPR PYGLDTEGAD ALAARLAAAA ERLVGVDDSA DVRDMGVVAV PSGGALPASL
SFDGTSVPVT WSATAADAVA ATAELATVDV TGRTSVKLAS GVYQRFSATA LVAPADLRYF
IDSGSSASGP GSLFTGVHQT FPQLLNDSTD QKWDGTTAGS TWGYSTAATT LAAGDPTDWG
SSYVGADYNK PVTYHLSLPA GTYQVVAVQA PRPGNTTQIY STVRAGGTAT RRTGTSTGAA
TPVAQTVTLT APGVVDVEFG TNGTSGYNAR LALVYVQQTQ G
//
