ID A0A1I1N2J9_9BACT Unreviewed; 1160 AA.
AC A0A1I1N2J9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=PAS domain S-box-containing protein {ECO:0000313|EMBL:SFC91894.1};
GN ORFNames=SAMN05421780_11247 {ECO:0000313|EMBL:SFC91894.1};
OS Flexibacter flexilis DSM 6793.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Flexibacteraceae;
OC Flexibacter.
OX NCBI_TaxID=927664 {ECO:0000313|EMBL:SFC91894.1, ECO:0000313|Proteomes:UP000199514};
RN [1] {ECO:0000313|EMBL:SFC91894.1, ECO:0000313|Proteomes:UP000199514}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6793 {ECO:0000313|EMBL:SFC91894.1,
RC ECO:0000313|Proteomes:UP000199514};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FOLE01000012; SFC91894.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I1N2J9; -.
DR STRING; 927664.SAMN05421780_11247; -.
DR OrthoDB; 1109395at2; -.
DR Proteomes; UP000199514; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00130; PAS; 2.
DR CDD; cd18773; PDC1_HK_sensor; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR43156:SF9; HAMP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF13426; PAS_9; 1.
DR Pfam; PF07228; SpoIIE; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00086; PAC; 2.
DR SMART; SM00091; PAS; 2.
DR SMART; SM00331; PP2C_SIG; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199514};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 343..395
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 657..727
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 731..782
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 782..853
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT COILED 616..667
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1160 AA; 130430 MW; 66C160EDB1D3FC9B CRC64;
MFRKITVGKK ITMTVLAVVM LSVVILSFIA FKLSQQAVMN RYMESINVIA DIKAQRIDSY
FKNQQTRLKF LQELSVLKDA LRANSGAPAA DGLEAMAAAE SVDFGAAAAP TVDFKPILDP
LLETYGYANL YLVSPDGKFL YNAHEGNDDE QTAESFNDPD GNTLREAAKG VYFSSVYKGI
DNHLYMLLAA PIKDEADHVG GIIIGKLNMT ELYGLIQDTI GLGKTGETIV GKLFEGSRKV
VFQNSLRHHD GAALRKEVIV GEASMRPLQE AVKKQNGFGV ETDYRREVTL SAWRYLPIVN
WGMVVKIDQS EVLEPTQKLK LIFFSVGLLI FLVSAIVTTI FSRALTNPLL NLKETMLLLG
KGILPNQIQQ RSSDEIGEMT ATVNQLVEGL KRTANFAHKI GEGDFQADFK PMSEGDTLGV
SLMNMRQSLQ DASKRDDERN WIVRGVAEIG EILRRHNEIA SLGDEIVSFI TNKVGAIQGA
FYVVDRQENG KTSIELKSSY AYNKKKYLSA KFNFGEGLVG QAAIEQDTIL RTEIPYDYVS
ITSGLLGDRR PSCILIVPLI TNEEVNGVLE LAGFERFAPA QVRFVQEISQ IIARTIFNIQ
VNERTRNLLA ASQKMSFELQ QQQEELRQNA EEMAATQEEL KRSNIQLEEQ IEEVNRTQKR
MQVLLENASE VITIYEEDGT IRYISPSVEK ILGYRPEEMI GIKDIVYVHE EGVAAVDKMF
ADLMADPDHT ITIQFSYMRK NGERIWLEAT GTNLLSDPAI EGIVVNSRDI TERRRAEKES
RMRGQMQALS ENSPDLITRV NKEGKFFYIN PVIEQYTGVK PSDLLRTNIN ETSLEGGLLE
AWRNIIDQVL EKQDKVATEI DFNSFMGNRM MHVSAIPEYN EEQRLESVLL VSHDITERKL
IELEIQTKNK KITESINYAK RIQVAILPDN ETIQYTFPDS FILYKPRDVV SGDFPWFLQK
DDDIFIAAVD CTGHGVPGAL ISLIGYFLLN NVLKDFSDTG TILDSLDEAV TKTLRQDGGD
SATRDGMDIA LCRINKTTRQ MQFSGAHRPL YYLSANGELE EIKGDKFPIG GGQYKNRSNF
ATRTIDYNDG DVLVFCSDGF PDQFGGRDNR KFSPKRIREI LQNNGSKPMM ELSNIYDTEF
EEWKGDGKQT DDVLMIGIRL
//
