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Database: UniProt
Entry: A0A1I1NYS2_9GAMM
LinkDB: A0A1I1NYS2_9GAMM
Original site: A0A1I1NYS2_9GAMM 
ID   A0A1I1NYS2_9GAMM        Unreviewed;       359 AA.
AC   A0A1I1NYS2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   08-MAY-2019, entry version 7.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=SAMN05660831_00349 {ECO:0000313|EMBL:SFC98870.1};
OS   Thiohalospira halophila DSM 15071.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Thiohalospira.
OX   NCBI_TaxID=1123397 {ECO:0000313|EMBL:SFC98870.1, ECO:0000313|Proteomes:UP000198611};
RN   [1] {ECO:0000313|EMBL:SFC98870.1, ECO:0000313|Proteomes:UP000198611}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HL3 {ECO:0000313|EMBL:SFC98870.1,
RC   ECO:0000313|Proteomes:UP000198611};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; FOMJ01000001; SFC98870.1; -; Genomic_DNA.
DR   BioCyc; GCF_900112605:BM272_RS01725-MONOMER; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000198611; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000198611};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198611};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       44    335       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
FT   COILED       69     93       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   359 AA;  39001 MW;  37031F40D32850DB CRC64;
     MSHRTEDLRI TNIKEVISPV QLHQSLPLSD AAAETVFGSR EAIHRILTGE DDRLLVIMGP
     CSIHDPEAAR EYADRLKALK EELAEDIELV MRVYFEKPRT TVGWKGLIND PDLDGSFRIN
     KGLRLARGLL TDLAEKGVPA ATEFLDLISP QYIADLVAWG AIGARTTESQ VHRELASGLS
     CPVGFKNGTD GSLKIAIDAI RSAAHPHHFM SLTREGRSAI FSTAGNEDTH IILRGGNDGP
     NYDAEHVAAA AAELDDAGLP SRLMVDCSHA NSRKDPQRQL EVARDVAGQI TGGENRIIGL
     MLESHLQGGR QEISDDMAYG QSVTDACLGW EDSVTAARLL AEAVRTRRAR GETREAAST
//
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