ID   A0A1I1QEX8_9ACTN        Unreviewed;       445 AA.
AC   A0A1I1QEX8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Hyaluronan synthase {ECO:0000313|EMBL:SFD16670.1};
GN   ORFNames=SAMN05421773_110250 {ECO:0000313|EMBL:SFD16670.1};
OS   Streptomyces aidingensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=910347 {ECO:0000313|EMBL:SFD16670.1, ECO:0000313|Proteomes:UP000199207};
RN   [1] {ECO:0000313|EMBL:SFD16670.1, ECO:0000313|Proteomes:UP000199207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.5739 {ECO:0000313|EMBL:SFD16670.1,
RC   ECO:0000313|Proteomes:UP000199207};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FOLM01000010; SFD16670.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I1QEX8; -.
DR   STRING; 910347.SAMN05421773_110250; -.
DR   OrthoDB; 9763050at2; -.
DR   Proteomes; UP000199207; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd06434; GT2_HAS; 1.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR22913; HYALURONAN SYNTHASE; 1.
DR   PANTHER; PTHR22913:SF12; N-ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR   Pfam; PF13641; Glyco_tranf_2_3; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199207};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        304..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        334..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        365..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          400..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..416
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   445 AA;  50209 MW;  95798DC6986F0CD9 CRC64;
     MSDFTQGIWS WIVVAVGETS WRELMPLGLA GIFVWALWLY RAVLSRFARP VKNDFRTTVS
     VVVPAYREDP DILMECLDSW LDQDPTEIII VPDVEDTEVL RRLRTVTDRR VRVLAFEHRG
     KRSALGVGIR AATSELVVLV DSDTRWEPGL LAAVQMPFED PSVGGVGTQQ NVYQRTTSVW
     RRMADWLVNL RYYDYVPAMG RAGAVACLSG RTAAYRREAI VPVLENLENE FFLGRRCVAG
     DDGRLTWLVL ASGYRTVHQS SARAISMFPS SFRAFVKQRV RWSRNSYRCY LTALYKGWLW
     RVPLVTKITV LQILLTPVTM GMALGYLLLS RLELTGRGLI LVLIWLLVGR GIRGWSHLRR
     HPQEILLLPL LATVVIMISL PIKLYAFITM NKQGWLTRSS TSVGGEGQTA ATLTGTGSGP
     RAPRPRTHHG DPEQTMELDV KAVRI
//