ID A0A1I1SFL2_9LACO Unreviewed; 813 AA.
AC A0A1I1SFL2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA translocase FtsK {ECO:0000256|ARBA:ARBA00020887};
GN ORFNames=SAMN04487792_0905 {ECO:0000313|EMBL:SFD45112.1};
OS Lactobacillus bombicola.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=1505723 {ECO:0000313|EMBL:SFD45112.1, ECO:0000313|Proteomes:UP000199599};
RN [1] {ECO:0000313|Proteomes:UP000199599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R-53102 {ECO:0000313|Proteomes:UP000199599};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA.
CC {ECO:0000256|ARBA:ARBA00025923}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
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DR EMBL; FOMN01000004; SFD45112.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I1SFL2; -.
DR STRING; 1505723.SAMN04487792_0905; -.
DR Proteomes; UP000199599; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR025199; FtsK_4TM.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF13491; FtsK_4TM; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 473..670
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 237..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 490..497
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 813 AA; 90465 MW; 60C602B9A2BA4444 CRC64;
MPKKKRKTTK ARKKVQKTDM TWAIVGLIQL SIAITAFTKF GNLGKQVANF FRLFVGDSYL
LIAGICIVFG LVMLIYNRPM HFKFKRSCGL FLAILGFLLV QSSNYFAHEL VNNAFMNVFW
YEMQAEFMRV SITKSVGGGI IGAMCYQFLY PLFGHIGIKI IAILFIPIGI LMFFDIKFAD
IIRKFQLFSQ LFISKNKEAS SKIKNQYNII RTKQVERREN KKVQDLADPL AEEPLEFPNV
TDFNEQTEKN DDSQNDDETE ISESSATAES NSAIEEEKFE PPIQIASEND EKANSPLEET
DLPRPHSFVA EDQKLQREIS NVEHVASRQT KQIKQKYQKP PLSLLDAVKN IDQSSDKALI
RKNTQTLQTT FKSFGVNVII KKAILGPTIT RYEVQPAVGV KVSRIVNLAD DLALALAAKD
IRIEAPIPGK PFIGIEVPNR TNSVVAFKDV MQNQDKKAQA DPMEVPLGKD VTGQIISANL
AKMPHLLIAG STGSGKSVAI NTILTSILMK ANPDQVKLIL IDPKMVELSV YSGVPHLSIP
VVTDPKLAAN ALNKAVKEME RRYKLFAASG ARNMGEFNEK VRINNQDKAN PVMNPLPYIL
VVVDELSDLM MVGGHDVEGA IVRLGQMARA AGIHMILATQ RPSVDVITGL IKANVPSRIS
FAVSSGIDSR TILDQTGADK LLGRGDMLYM PVGAAKPERI QGAYVSSHEV EKVIAWVKEQ
QQPEYDQELI PKKGEEMTEN AADEPVDELY DQAVDMVQRQ QAASVSMLQR RFRIGYNRAA
RIVDEMEARG VVGPSEGSKP RQVLVKPTKD QTK
//
