ID A0A1I1Y6C7_9FIRM Unreviewed; 287 AA.
AC A0A1I1Y6C7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00015486};
DE EC=2.4.2.21 {ECO:0000256|ARBA:ARBA00011991};
DE AltName: Full=N(1)-alpha-phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00030686};
GN ORFNames=SAMN05216245_10245 {ECO:0000313|EMBL:SFE14882.1};
OS Succiniclasticum ruminis DSM 9236.
OC Bacteria; Bacillota; Negativicutes; Acidaminococcales; Acidaminococcaceae;
OC Succiniclasticum.
OX NCBI_TaxID=1123323 {ECO:0000313|EMBL:SFE14882.1, ECO:0000313|Proteomes:UP000198896};
RN [1] {ECO:0000313|EMBL:SFE14882.1, ECO:0000313|Proteomes:UP000198896}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 9236 {ECO:0000313|EMBL:SFE14882.1,
RC ECO:0000313|Proteomes:UP000198896};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide =
CC alpha-ribazole 5'-phosphate + H(+) + nicotinate;
CC Xref=Rhea:RHEA:11196, ChEBI:CHEBI:15378, ChEBI:CHEBI:15890,
CC ChEBI:CHEBI:32544, ChEBI:CHEBI:57502, ChEBI:CHEBI:57918; EC=2.4.2.21;
CC Evidence={ECO:0000256|ARBA:ARBA00001058};
CC -!- PATHWAY: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-
CC ribazole from 5,6-dimethylbenzimidazole: step 1/2.
CC {ECO:0000256|ARBA:ARBA00005049}.
CC -!- SIMILARITY: Belongs to the CobT family.
CC {ECO:0000256|ARBA:ARBA00007110}.
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DR EMBL; FONL01000002; SFE14882.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I1Y6C7; -.
DR STRING; 1123323.SAMN05216245_10245; -.
DR OrthoDB; 9781491at2; -.
DR UniPathway; UPA00061; UER00516.
DR Proteomes; UP000198896; Unassembled WGS sequence.
DR GO; GO:0008939; F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1610.10; -; 1.
DR Gene3D; 3.40.50.10210; -; 1.
DR InterPro; IPR003200; Nict_dMeBzImd_PRibTrfase.
DR InterPro; IPR023195; Nict_dMeBzImd_PRibTrfase_N.
DR InterPro; IPR036087; Nict_dMeBzImd_PRibTrfase_sf.
DR PANTHER; PTHR43463; NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR43463:SF1; NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE; 1.
DR Pfam; PF02277; DBI_PRT; 2.
DR SUPFAM; SSF52733; Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT); 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000313|EMBL:SFE14882.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198896};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SFE14882.1}.
SQ SEQUENCE 287 AA; 31264 MW; 17FDC62F93095BB0 CRC64;
MHIEELITKI QPLSGDIIKA AQKRFDNLIK PVGSLALLES MTARYAGILG SSDKQLVVIP
ENRLLLLWGE MKHAAEIETA MLKKKAVSVY ASHVSAKVIP LLVIGESAYD LLEEGAMLTA
EYIAEEQSGL ICLGTFEKEL RPDWQDLPEE EDGLAFLDRL QCPAVAAMTG AILQAAGMRV
PVMLDGVATC LAALAASKFN PYVLQYCFAG DESAETGSAA LLQKLQLQAP LRLSLHNAEG
VGALTCLRLF DAGIKAYREM ETFEEAGVHN EKEDYSLKVQ EDKKLKG
//
