ID A0A1I1YV90_9PROT Unreviewed; 399 AA.
AC A0A1I1YV90;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=acetyl-CoA C-acyltransferase {ECO:0000256|ARBA:ARBA00024073};
DE EC=2.3.1.16 {ECO:0000256|ARBA:ARBA00024073};
GN ORFNames=SAMN05428977_101022 {ECO:0000313|EMBL:SFE22898.1};
OS Nitrosomonas sp. Nm166.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Nitrosomonadaceae; Nitrosomonas.
OX NCBI_TaxID=1881054 {ECO:0000313|EMBL:SFE22898.1, ECO:0000313|Proteomes:UP000199102};
RN [1] {ECO:0000313|EMBL:SFE22898.1, ECO:0000313|Proteomes:UP000199102}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nm166 {ECO:0000313|EMBL:SFE22898.1,
RC ECO:0000313|Proteomes:UP000199102};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; FONE01000010; SFE22898.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I1YV90; -.
DR STRING; 1881054.SAMN05428977_101022; -.
DR OrthoDB; 6139495at2; -.
DR Proteomes; UP000199102; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF8; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:SFE22898.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199102};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:SFE22898.1}.
FT DOMAIN 9..268
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 277..397
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 95
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 355
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 385
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 399 AA; 42429 MW; 20D646822863ED1A CRC64;
MTKQTQEAYI VAAARTPVGK APRGMFRNVR PDDMLVHVLQ TVMKQCEGLD PAAVEDVIVG
CAMPEAEQGI NVARVALLLA GLPDHVAGMT INRFCSSGLQ SVALAADRIR LGEADVMIAG
GTESMSMIPM MGNKVAINPA MFEHEENVAI AYGMGITAEK VAEQWKVSRE DQDEFALTSH
LRALKAIETG EFKDEIAPYQ VDEKRPDLAT HQVHEEIVIK GTDEGPRADT NLEALAKLKP
VFAAQGSVTA GNSSQMSDGA GAVVLMSEAA MRSFNLSPIG RFIGFSVVGV PPEIMGVGPI
KAIPKVLAQT GIKQDDLDWI ELNEAFAAQS LAVIRELGLD RNKVNPLGGA IALGHPLGAT
GSIRVATLLH GLRRHQQKYG MVTMCIGTGM GAAGIFEAL
//
