ID   A0A1I2AKI2_9BACT        Unreviewed;       978 AA.
AC   A0A1I2AKI2;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=SAMN05444380_11193 {ECO:0000313|EMBL:SFE44422.1};
OS   Thermophagus xiamenensis.
OC   Bacteria; Bacteroidota; Bacteroidia; Marinilabiliales; Marinilabiliaceae;
OC   Thermophagus.
OX   NCBI_TaxID=385682 {ECO:0000313|EMBL:SFE44422.1, ECO:0000313|Proteomes:UP000181976};
RN   [1] {ECO:0000313|EMBL:SFE44422.1, ECO:0000313|Proteomes:UP000181976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19012 {ECO:0000313|EMBL:SFE44422.1,
RC   ECO:0000313|Proteomes:UP000181976};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR   EMBL; FONA01000011; SFE44422.1; -; Genomic_DNA.
DR   RefSeq; WP_010526441.1; NZ_FONA01000011.1.
DR   AlphaFoldDB; A0A1I2AKI2; -.
DR   STRING; 385682.SAMN05444380_11193; -.
DR   eggNOG; COG0587; Bacteria.
DR   InParanoid; A0A1I2AKI2; -.
DR   OrthoDB; 9803237at2; -.
DR   Proteomes; UP000181976; Unassembled WGS sequence.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; PHP domain-like; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000181976};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          6..67
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
SQ   SEQUENCE   978 AA;  112718 MW;  86D2B638B7368FCF CRC64;
     MIAGKSYYSL RFGTLSPEEL AATAAKQGID VLILTDINNT TGIFEFVKAC QQNKITPLVG
     IEFRNNSQWL YTGIAKNFKG FGELNRFLSH YRLQGQPLPA NPPSFHDAII VWPWGNKTPQ
     QLKDNEYIGI RHFQLRQLLT SPWRNHQERI LIWQPVVFNN RQDMELHRQL RAIDRNILLD
     RLSPDDLASP YDWMVPHQKL LKAFSDWPEI IKTTNTLLKQ LSFDFSFEGS KNKQTYTGSR
     YDDEQLLAQL ASDGLKERYG PDNVVARQRV EKELSIINKL GFAAYYLMVW DIIRYSLSHG
     FYHVGRGSGA NSVVAYCLKI TDVDPIELNL YFERFLNPKR SSPPDFDIDY SWKEREEVQN
     YIFKRYGRAH TALLGAVSTF QARAAIRELG KIYGLPREEI DQLVLQPRGF EPDNLGKMIL
     KTAHRLAGFP NLRTIHAGGI LISEAPITDY TALDMPPKGF STTQWDMYTA EEIGFEKFDI
     LSQRGIGHIR DCINIVYQNH GKNIDIHRID DFKKDTKIKK LLQKGETTGC FYIESPAMRG
     LLKKLRCRDY LTLVAASSII RPGVARSGMM REYIRRFHNP DSFEYAHPIL KEQLSETFGI
     MVYQEDVIKV CHHFAGLDLA DADVLRRAMS GKYRSRKAFQ SIVDKFFANC HQRGYDKALT
     AEVWRQIESF AGYSFSKAHS ASYAVESFQS LYLKAHYPLE FMVAVINNFG GFYATWLYVN
     EARRLGGIIH LPCVNKSQYM TSISGKDIYL GFIHVHDLEQ KTALAIIKER NRNGVYHSLE
     DFVSRTGITR EQLLLLIRLG AFRFTGKSKP QLLWEAHLLL SKEKKKKKAP RLFNPATQQY
     RLPQLQQQKL EDAYDEIELL GFPVSCSFFD MLKTSYRGEL LARDLQHNVG RRVRMTGQLV
     TIKYVKTVKR QIMHFATFLD PDGEFFDTVH FPKVVKRWPF AGNGVYLIQG KIVSEFGYPS
     IEVEKMAPLP LRPDPRSE
//