ID   A0A1I2B4W1_9ACTN        Unreviewed;       401 AA.
AC   A0A1I2B4W1;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=HNH endonuclease {ECO:0000313|EMBL:SFE50938.1};
GN   ORFNames=SAMN05216574_10448 {ECO:0000313|EMBL:SFE50938.1};
OS   Blastococcus sp. DSM 46838.
OC   Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC   Geodermatophilaceae; Blastococcus.
OX   NCBI_TaxID=1798228 {ECO:0000313|EMBL:SFE50938.1, ECO:0000313|Proteomes:UP000198589};
RN   [1] {ECO:0000313|Proteomes:UP000198589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 46838 {ECO:0000313|Proteomes:UP000198589};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family.
CC       {ECO:0000256|ARBA:ARBA00023450}.
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DR   EMBL; FOND01000004; SFE50938.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I2B4W1; -.
DR   STRING; 1798228.SAMN05216574_10448; -.
DR   OrthoDB; 5177627at2; -.
DR   Proteomes; UP000198589; Unassembled WGS sequence.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00085; HNHc; 1.
DR   Gene3D; 1.10.30.50; -; 1.
DR   InterPro; IPR003870; DUF222.
DR   InterPro; IPR002711; HNH.
DR   InterPro; IPR003615; HNH_nuc.
DR   Pfam; PF02720; DUF222; 1.
DR   Pfam; PF01844; HNH; 1.
DR   SMART; SM00507; HNHc; 1.
PE   3: Inferred from homology;
KW   Endonuclease {ECO:0000313|EMBL:SFE50938.1};
KW   Hydrolase {ECO:0000313|EMBL:SFE50938.1};
KW   Nuclease {ECO:0000313|EMBL:SFE50938.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198589}.
FT   DOMAIN          315..367
FT                   /note="HNH nuclease"
FT                   /evidence="ECO:0000259|SMART:SM00507"
SQ   SEQUENCE   401 AA;  42895 MW;  9EBF2646E2A6DDB2 CRC64;
     MGELQSALDA LAAEDVRALP PRRQLEGVAE LLEARNRIDA QLARRVRAAE LQQAPEDDGK
     KTMASWLRGH GRLASKVAGQ TVRIGRALEH LPALEAAFAA GAVSADQVAV VAPVVTPGRR
     AAALEQGIDL AEVDRMLAAV AAQHDVQRLS RVVHHYLSRL DPDGPEPDPT DERSFTVSTM
     SDGTVVLRGQ LDTIGGEKLK AALESVIQAD RPKGDLRTRA QQSADALVQL ADNQLASGGL
     PILRRVKPSV AVTVGAADLA APATGPAAAT TGFGSRVSAE TARMLACDGA VTVFRLDEHG
     KPLNVGRTTR SWPPHLRKAV EIRDDTCVFA GCGAPKHWCD VHHLIHWAFG GETSLDNAAL
     LCERHHTKVH HGFRVQRDPG GRWRTFRPDG SEIVIGTSLL V
//