ID A0A1I2B7S0_9FIRM Unreviewed; 776 AA.
AC A0A1I2B7S0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=SAMN05216245_10838 {ECO:0000313|EMBL:SFE52047.1};
OS Succiniclasticum ruminis DSM 9236.
OC Bacteria; Bacillota; Negativicutes; Acidaminococcales; Acidaminococcaceae;
OC Succiniclasticum.
OX NCBI_TaxID=1123323 {ECO:0000313|EMBL:SFE52047.1, ECO:0000313|Proteomes:UP000198896};
RN [1] {ECO:0000313|EMBL:SFE52047.1, ECO:0000313|Proteomes:UP000198896}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 9236 {ECO:0000313|EMBL:SFE52047.1,
RC ECO:0000313|Proteomes:UP000198896};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
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DR EMBL; FONL01000008; SFE52047.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I2B7S0; -.
DR STRING; 1123323.SAMN05216245_10838; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000198896; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SFE52047.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198896};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 2..144
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 776 AA; 87730 MW; 702B3BF162ABD003 CRC64;
MQTLYIAEKP DIAKAIADYL WPSGGYKKGT GFYRKDDTIV SWAVGHLLEL ATPEAYDKRY
ARWTNYRIFP AVWQHEVIAR SSAQFKVVAG LLRTADEVIH AGDPDREGQL LIEEILHYCN
YCGRVRRLLI NAKDDVSMKR AFENIEDNTK YENLYAAGLA REQADWLVGI NLTRCYTTNA
SKFSPGAVWN IGRVKVPTLA LVVNREKEIR NFVVHKYYEL KAAFTKEGIR FTALWHPDEK
KIALDEDGRL LDKLVAEAVQ QKVLPADGIV QKVTRKKGTE APPLPYSLDT LQVEANARFG
ISPKLALSTV QSLYEKKFVS YPRSDCNYIP KAQHKEAFRI LKKLAGRNVR GAEQADPKLY
SRAWNDKKVT AHHAIIPTGE IPQQLSATEE KIYTMIAERY VMQFYPPCEF ETITFEILLA
DELFKGSGKV ILKPGFKAVF MTQGKKKDTA DTDSEEENLS LPNLVKGENL GKPDAVDLLE
KETKPPKRFT EGTLLAAMAN IYRFMDPKNP NREKLKEVKG IGTPATRDTI ISELQGIRGS
KQTQMPFMEK VKKELVPTEL GFQLIDNVDL SLTKPDTTAE MEFALAEIAA GGGSVEQFRQ
DIYNTIDRNI TYAEGHQFPG YELVKCPLCK TGSLVKHFSR KTKKAFFVCD NPACVSPVTG
KPVYYNVDKN GQPVMKQQEA APAKTYTCPV CGKETLNCHY SAKTKQHFYV CDDKKCVSPV
TKKIVFYAVD KTGNPVIEYC PKDNVILEKK KSRYGFFWAC PQCKTIYKDN KGRPKI
//
