ID A0A1I2C6E9_9BACT Unreviewed; 693 AA.
AC A0A1I2C6E9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Acyl-peptide hydrolase {ECO:0000256|ARBA:ARBA00032596};
DE AltName: Full=Acylaminoacyl-peptidase {ECO:0000256|ARBA:ARBA00032284};
GN ORFNames=SAMN04488541_100499 {ECO:0000313|EMBL:SFE63722.1};
OS Thermoflexibacter ruber.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Thermoflexibacteraceae;
OC Thermoflexibacter.
OX NCBI_TaxID=1003 {ECO:0000313|EMBL:SFE63722.1, ECO:0000313|Proteomes:UP000199513};
RN [1] {ECO:0000313|EMBL:SFE63722.1, ECO:0000313|Proteomes:UP000199513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GEY, DSM 9560 {ECO:0000313|Proteomes:UP000199513};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FONY01000004; SFE63722.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I2C6E9; -.
DR STRING; 1003.SAMN04488541_100499; -.
DR OrthoDB; 9812921at2; -.
DR Proteomes; UP000199513; Unassembled WGS sequence.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008242; F:omega peptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR002471; Pept_S9_AS.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR42776:SF27; DIPEPTIDYL PEPTIDASE FAMILY MEMBER 6; 1.
DR PANTHER; PTHR42776; SERINE PEPTIDASE S9 FAMILY MEMBER; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF07676; PD40; 2.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Aminopeptidase {ECO:0000313|EMBL:SFE63722.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000313|EMBL:SFE63722.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199513};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..693
FT /note="Acyl-peptide hydrolase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011492626"
FT DOMAIN 292..382
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 494..692
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 693 AA; 76710 MW; 4CB7C29B8C51C77E CRC64;
MKQLTLLTYF LLISLCLSAQ SFSIDQVLSS PFTTELKASP KGNKIALVMN RQGERNIWLS
ENSGSNFKQI TSYQGDNGQE ISSLAFTPES NALIFVRGGA PNASGEIPNP AELQESVERA
IWKIDTDGKN LKKLAVGFYP KLSPKGDILA YLTGGQVWTM RLDSLKASKL FQTRGSQSAI
RWSPDGSKLA FVSSRNDHSF VGIYDFNTKS ISFLSPSTDL DGHPVWSPDG KQIAFIRVRS
NRDALIFGPK REGLPWSIWV AEVATGKAKK VWEAKKGRGS NFFSNALNSS SPENPLFWTS
DNYLIFPYEG DGWQHLYAVP ANGGEAKLLT AGEGEVEFVT LAKDGKSVIY NSNIGDIDRR
HLWQVAATSA PKQLTSGNGI EWGMAQAEDG TIFCIRSDAK MPARPAVLKN GKLEDLATEL
MPKDFPANQL VEPQAVMITA TDGMMIPCQL FLPKNHKAGE KHPGAIFFHG GSRRQMLLGF
NYGDYYHKAY ALNQYLASQG YVVLSVNYRS GIGYGMEFRE ALNYGATGAS EYADVVGAGL
YLKSRDDVNG SKIGLWGGSY GGYLTALGLA RASDLFACGV DIHGVHDWNV VVRNFIPSYD
AGKRTDWAKR AFESSPMHFL DGWKSPVLLI HGDDDRNVPF SETVTLAEQL SHRNIYFEYL
IFPDEVHSFL LHKNWLEAYK ATADFFDRFL KNK
//
